李莉

【摘要】 目的：探究氯吡格雷与阿托伐他汀钙联合治疗短暂性脑缺血发作患者的效果，以及对患者脑血流的改善作用。方法：选取2019年1月-2020年6月笔者所在医院收治的短暂性脑缺血发作患者100例为研究对象。按照随机数字表法将其分为研究组和对照组，每组50例。两组患者均进行常规治疗，在此基础上对照组给予氯吡格雷治疗，研究组给予氯吡格雷联合阿托伐他汀钙治疗。对比两组患者的治疗效果、治疗前后的脑血流情况、血清相关指标及不良反应发生情况。结果：研究组治疗总有效率为94.00%，明显高于对照组的80.00%，差异有统计学意义（P<0.05）。两组治疗前脑血流指标比较，差异均无统计学意义（P>0.05）;治疗后，两组脑血流指标均较治疗前改善，且研究组Qmean、R、Vmax、Vmin均优于对照组，差异均有统计学意义（P<0.05）。两组治疗前血清相关指标比较，差异均无统计学意义（P>0.05）;治疗后，两组血清MDA、hs-CRP、IL-6水平均较治疗前降低，SOD水平均较治疗前升高，差异均有统计学意义（P<0.05）。研究组治疗后血清MDA、hs-CRP、IL-6水平均明显低于对照組，SOD水平明显高于对照组，差异均有统计学意义（P<0.05）。研究组不良反应发生率为8.00%，虽低于对照组的12.00%，但差异无统计学意义（P>0.05）。结论：对于短暂性脑缺血发作患者，应用氯吡格雷与阿托伐他汀钙联合治疗的效果较好，可有效改善患者的脑血流状态及血清指标水平，且并未明显增加不良反应的发生情况，安全性较高。

【关键词】 氯吡格雷 阿托伐他汀钙 短暂性脑缺血发作 脑血流

Effect of Clopidogrel Combined with Atorvastatin Calcium on Cerebral Blood Flow in Patients with Transient Ischemic Attack/LI Li. //Medical Innovation of China， 2021， 18（33）： 00-012

[Abstract] Objective： To explore the effect of Clopidogrel combined with Atorvastatin Calcium in the treatment of patients with transient ischemic attack， as well as the improvement of cerebral blood flow. Method： A total of 100 patients with transient ischemic attack in our hospital from January 2019 to June 2020 were selected as the research objects. According to the random number table method， they were divided into the study group and the control group， with 50 cases in each group. Patients of the two groups were treated with conventional treatment， on this basis， the control group were treated with Clopidogrel， the study group were treated with Clopidogrel combined with Atorvastatin Calcium. The treatment effect， cerebral blood flow before and after treatment， serum related indicators and adverse reactions of the two groups were compared. Result： The total effective rate of the study group was 94.00%， which was significantly higher than 80.00% of the control group， the difference was statistically significant （P<0.05）. The cerebral blood flow indexes of the two groups before treatment were compared， and there were no statistical significance （P>0.05）; after treatment， the cerebral blood flow indexes of the two groups were improved compared with those before treatment， and the Qmean， R， Vmax and Vmin of the study group were better than those of the control group， the differences were statistically significant （P<0.05）. The serum related indexes of the two groups were compared before the treatment without statistical significance （P>0.05）; after treatment， the serum MDA， hs-CRP， IL-6 levels of the two groups were all decreased compared with the before treatment， the SOD level was increased compared with the before treatment， the differences were statistically significant （P<0.05）. After treatment， serum MDA， hs-CRP and IL-6 in the study group were significantly lower than those in the control group， and the level of SOD was significantly higher than that in the control group， the differences were statistically significant （P<0.05）. The incidence of adverse reactions in the study group was 8.00%， lower than 12.00% in the control group， but the difference was not statistically significant （P>0.05）. Conclusion： For patients with transient ischemic attack， the effect of Clopidogrel combined with Atorvastatin Calcium treatment is better， which can effectively improve the cerebral blood flow status and serum index levels of patients， and does not significantly increase the incidence of adverse reactions， with high safety.

[Key words] Clopidogrel Atorvastatin Calcium Transient ischemic attack Cerebral blood flow

First-author’s address： Jining Second People’s Hospital， Jining 272000， China

doi：10.3969/j.issn.1674-4985.2021.33.003

近年来随着人口结构老龄化问题的加重，以及生活及工作压力大、作息不规律等，导致短暂性脑缺血发作的患病率呈现上升的趋势。……