赵娜 邱国萍 赵云艽

[摘要] 目的 探讨尿毒清颗粒联合前列地尔治疗慢性肾功能衰竭的临床疗效。 方法 随机选取2019年3月至2020年2月我院收治治疗的慢性肾功能衰竭患者60例，将患者分为研究组和对照组，每组各30例，均接受常规治疗，研究组给予尿毒清颗粒联合前列地尔治疗，对照组给予单独前列地尔治疗，观察两组患者临床症状，对患者血尿素氮和血尿酸等生化指标进行检查，对比两组患者的治疗效果，观察两组患者用药治疗期间是否出现呕吐不适等不良反应。 结果 研究组患者治疗总有效率明显高于对照组（P<0.05），在对患者治疗的过程中，研究组血尿素氮水平、血尿酸水平与对照组比较，差异有统计学意义（P<0.05），两组患者治疗过程中，均没有出现严重不良反应。结论 使用尿毒清颗粒和前列地尔联合治疗慢性肾功能衰竭，可有效改善患者的肾功能，同时可提升患者的临床治疗效果，且治疗安全性较高。

[关键词] 尿毒清颗粒;前列地尔;慢性肾功能衰竭;不良反应

[Abstract] Objective To explore the clinical efficacy of Niaoduqing Granules combined with alprostadil in the treatment of chronic renal failure. Methods A total of 60 patients with chronic renal failure who were admitted to our hospital from March 2019 to February 2020 were randomly selected. They were divided into study group and control group， with 30 cases in each group. All were given conventional treatment. The study group was given Niaoduqing Granules combined with alprostadil， while the control group was given alprostadil alone The clinical symptoms were observed in both groups of patients. The patient's blood urea nitrogen and blood uric acid were tested. The treatment effects were compared between the two groups， and whether the two groups of patients showed adverse reactions such as vomiting and discomfort during medication were observed. Results The total effective rate of treatment in the study group was significantly higher than that in the control group（P<0.05）. There were significant differences in blood urea nitrogen and uric acid between the study group and the control group（P<0.05）. There were no serious adverse reactions in the two groups. Conclusion When combined with Niaoduqing Granules and alprostadil in the treatment of patients with chronic renal failure， it can effectively improve the patient's renal function. At the same time， the clinical treatment effect is also significantly improved， and the safety of the treatment is relatively high.

[Key words] Niaoduqing Granules; Alprostadil; Chronic renal failure; Adverse reactions

慢性肾功能衰竭又被称为慢性肾功能不全，指由于多种原因发生的人体肾脏实质损害情况，使患者肾脏发生萎缩，而导致患者无法维持正常的肾功能，也比较容易导致患者出现电解质紊乱和营养物质代谢障碍等情况，对患者的生活质量造成不利影响，甚至在严重的情况下，患者会出现死亡[1-3]。当前对慢性肾功能衰竭患者治疗的主要方式包含透析和药物疗法及肾移植等[4]，由于通过透析法和肾移植方式进行治疗时所花费的费用比较高，不易被患者所接受，故早期慢性肾功能衰竭多进行药物治疗，能有效延缓患者慢性肾功能衰竭的进展，在临床治疗中应用比较广泛[5-6]。本研究选取2019年3月至2020年2月我院收治的慢性肾功能衰竭患者，研究和分析尿毒清颗粒联合前列地尔治疗对该疾病的治疗效果，现报道如下。……