李凌霄 郄永强 李圆圆 刘淑娟 王静

【摘要】 目的 探讨干燥综合征（Sjgren's syndrome，SS）患者唾液腺动态显像（salivary gland scintigraphy， SGS）及免疫相关指标的诊断价值。

方法 回顾性分析32例干燥综合征患者的唾液腺动态显像资料及免疫相关指标资料，通过唾液腺动态影像及时间-放射性曲线将干燥综合征患者分为功能正常组、轻度损伤组、中度损伤组和重度损伤组，比较各组间免疫相关指标的差异。

结果 各组间腮腺摄取指数和排泌分数比较差异均有统计学意义（P<0.05）。重度损伤组与功能正常组、重度损伤组与轻度损伤组类风湿因子（RF）比较差异均有统计学意义（P<0.05），重度损伤组与功能正常组血沉（ESR）比较差异有统计学意义（P<0.05）。各组间抗核抗体、抗SS-A/Ro60kD抗体、抗SS-A/Ro52kD抗体、抗SS-B/La抗体、C反应蛋白（CRP）比较差异无统计学意义（P>0.05）。

结论 RF、ESR水平较高的干燥综合征患者更易出现严重的唾液腺功能损伤，唾液腺动态显像联合免疫相关指标检查在干燥综合征的诊断及全面评价病情方面具有非常重要的临床价值。

【关键词】 干燥综合征;唾液腺动态显像;免疫相关指标

中图分类号：R593   文献标志码：A   DOI：10.3969/j.issn.1003-1383.2021.12.011

【Abstract】 Objective To explore the diagnostic value of salivary gland scintigraphy （SGS） and immune related indexes in patients with Sjgren's syndrome （SS）.

Methods SGS data and immune related indexes of 32 patients with SS were retrospectively analyzed. Based on SGS data and time-radioactivity curve， the SS patients were divided into four groups： normal function group， mildly injured group， moderately injured group and severely injured group. And then， the differences of immune related indexes among groups were compared.

Results There were statistically significant differences in parotid gland uptake ratio（UR） and excretion fraction（EF） between groups （P<0.05）. There was statistically significant difference of rheumatoid factor （RF） between the severely injured group and the normal function group， and that between the severely injured group and the mildly injured group （P<0.05）. And the difference of erythrocyte sedimentation rate（ESR） between the severely injured group and the normal function group was statistically significant（P<0.05）. While there were no statistically significant differences in anti-nuclear antibody， anti-SS-A/Ro60kD antibody， anti-SS-A/Ro52kD antibody anti-SS-B/La antibody and C-reactive protein （CRP） between groups（P>0.05）.

Conclusion Sjgren's syndrome patients with higher RF and ESR levels are more likely to have severe salivary gland function damage. Salivary gland scintigraphy combined with immune related indexes is of important clinical value in the diagnosis and comprehensive evaluation of Sjgren's syndrome.

【Key words】 SS; SGS; immune related indexes

干燥綜合征（Sjgren's syndrome，SS）是一种主要影响外分泌腺的慢性自身免疫性疾病，可为原发病，也可继发于其他自身免疫性疾病，该病在早期主要影响唾液腺和泪腺，随着病情发展可能累及身体的其他器官或系统[1]。干燥综合征患者临床表现多样，并且起病隐匿，早期诊断较为困难。目前，唾液腺动态显像、自身抗体检测已被广泛用于干燥综合征患者的诊断。……