李芸

[摘要] 目的 觀察脱敏舒鼻颗粒治疗鼻鼽肺气虚证的临床疗效。 方法 选取2019年6月至2020年8月景德镇市中医医院120例鼻鼽肺气虚证患者作为研究对象，按照随机数字表法分为观察组（脱敏舒鼻颗粒）、中药对照组（玉屏风颗粒）、西药对照组（盐酸左西替利嗪片），每组各40例。比较三组患者治疗前后中医证候积分及血清IgE指标，对比三组总有效率及不良反应发生率。 结果 三组患者各项中医证候积分治疗前比较，差异无统计学意义（P>0.05），治疗后均低于治疗前，观察组治疗后流清涕、鼻痒评分低于中药对照组及西药对照组，差异有统计学意义（P<0.05）;三组患者血清IgE指标治疗前比较，差异无统计学意义（P>0.05），治疗后均降低，观察组血清IgE指标治疗后低于中药对照组及西药对照组，差异有统计学意义（P<0.05）;观察组总有效率为90.0%，与中药对照组及西药对照组比较，差异无统计学意义（P>0.05）;观察组及中药对照组不良反应发生率分别为5.0%、7.5%，均低于西药对照组的25.0%，差异有统计学意义（P<0.05）。 结论 脱敏舒鼻颗粒应用于鼻鼽肺气虚证，在改善患者流清涕、鼻痒症状及血清IgE指标方面效果突出、不良反应少、疗效确切，可予以推广。

[关键词] 脱敏舒鼻颗粒;鼻鼽肺气虚证;玉屏风颗粒;血清IgE;不良反应;中医证候

[中图分类号] R276.1          [文献标识码] B          [文章编号] 1673-9701（2021）30-0085-04

[Abstract] Objective To observe the clinical efficacy of Tuomin Shubi Granules in the treatment of rhinorrhea and lung-qi deficiency syndrome. Methods From June 2019 to August 2020，A total of 120 patients with rhinorrhea and lung-qi deficiency syndrome in Jingdezhen Traditional Chinese Medicine Hospital were selected as the research objects.They were divided into observation group（Desensitizing Shubi granules） and traditional Chinese medicine control group（Yu Pingfeng granules），western medicine control group（levocetirizine hydrochloride tablets）according to the random number table，with 40 cases in each group.The scores of TCM syndromes and serum IgE indexes of the three groups before and after treatment were compared，and the total effective rate and incidence of adverse reactions were compared. Results There was no significant difference in the scores of various TCM syndromes of the three groups before treatment.After treatment，they were all lower than before treatment.After treatment，the scores of clear nose and nasal itching in the observation group were lower than those of the Chinese medicine control group and the western medicine control group，and the difference was statistically significant（P<0.05）.There was no statistically significant difference in serum IgE indicators of the three groups before treatment（P>0.05），and all decreased after treatment.After treatment，the serum IgE indicators of the observation group were lower than those of the traditional Chinese medicine control group and the western medicine control group，and the difference was statistically significant（P<0.05）.The total effective rate of the observation group was 90.0%，which was not statistically different from the traditional Chinese medicine control group and the western medicine control group（P>0.05）.The incidence of adverse reactions in the observation group and the traditional Chinese medicine control group were 5.0% and 7.5% respectively，lower than 25.0% of the western medicine control group，and the difference was statistically significant（P<0.05）. Conclusion Desensitizing Shubi granules used in rhinorrhea and lung-qi deficiency syndrome have outstanding effects in improving patients with runny nose，nasal itching symptoms，and serum IgE indicators，with few adverse reactions and definite curative effects，which can be promoted.

[Key words] Desensitizing Shubi granules; Rhinorrhea and lung-qi deficiency syndrome; Yupingfeng granules; Serum IgE; Adverse reactions; TCM syndromes

作为耳鼻喉科常见病，鼻鼽即变应性鼻炎，主要指患者机体与致敏原接触后，在IgE介导及免疫细胞因子参与下形成的以流涕、鼻塞为主要症状的慢性炎性疾病[1]。流行病学调查研究发现该疾病在青壮年及儿童群体有着较高的发病率，会增加哮喘风险，该疾病的发生是环境、基因等多种因素共同作用的结果[2]。……