黄丽

[摘要] 目的 观察在宫颈癌前病变的临床检查当中，HPV-DNA分型、TCT与阴道镜下宫颈活检联合应用的实际情况。方法 方便选择该院2015年1月—2019年5月门诊就诊的450例接受宫颈癌前病变检查的女性为研究对象，让其在门诊接受HPV-DNA分型、TCT筛查，阳性对象接受阴道镜下宫颈活检联合检查，对其诊断筛查情况进行分析。 结果 在所有接受检查的对象中，56例对象出现HPV阳性的情况，HPV16型9例， HPV18型3例，其他高危型有26例，低危型感染为 18例。 结论 针对宫颈癌前病变的临床检查，让接受检查对象接受HPV-DNA分型、TCT后再行阴道镜下宫颈活检的情况较好，该方法值得应用。

[关键词] 宫颈癌前病变;阴道镜;TCT; HPV-DNA分型;宫颈活检

[中图分类号] R711          [文献标识码] A          [文章编号] 1674-0742（2020）08（c）-0029-03

[Abstract] Objective To observe the actual situation of combined application of HPV-DNA typing， TCT and colposcopy cervical biopsy in the clinical examination of cervical precancerous lesions. Methods 450 cases of women who received cervical precancerous lesion examinations from January 2015 to May 2019 in the hospital were convenient selected as the research subjects， and their outpatient clinics received HPV-DNA typing and TCT screening， and positive subjects received colposcopy combined examination of lower cervical biopsy to analyze the diagnosis and screening situation. Results Among all the subjects examined， 56 subjects were HPV positive， 9 were HPV16， 3 were HPV18， 26 were other high-risk types， and low-risk infections were 18 cases. Conclusion For the clinical examination of precancerous lesions of the cervix， it is better for the subjects to undergo colposcopy cervical biopsy after HPV-DNA typing and TCT. This method is worthy of application.

[Key words] Cervical precancerous lesions; Colposcopy; TCT; HPV-DNA typing; Cervical biopsy

在世界范圍内的女性恶性肿瘤病变当中，宫颈癌都是十分常见的病变类型，且伴随我国女性个人生活习惯等多方面因素的变化，宫颈癌成为我国女性群体中的高发恶性肿瘤疾病，且患者数量在出现增多的同时，患者年龄也有了明显的年轻化趋势[1-2]。宫颈癌的致病因素主要就是HPV感染，这是目前人类癌症当中唯一可以确定发病原因的癌症类型，所以，宫颈癌是可以进行提前防治的，适龄女性如果定期接受宫颈癌前病变筛查，可以尽早发现是否出现病变情况[3-4]。宫颈癌前病变的筛查方式类型较多，最早的筛查手段是采取肉眼观察以及宫颈刮片方式，但这两种筛查方式存在极高的误诊率及漏诊率，目前已经被临床淘汰。而后基于愈……