汪倩　李咏　鲜燕　王英　文翔

[摘要]目的：评价含有西藏温泉水的修护霜（商品名：珀芙研舒缓保湿修护霜）对于敏感性皮肤的辅助治疗作用和安全性。方法：患者使用珀芙研舒缓保湿修护霜，早晚各1次，连续使用28d。入组前和试验结束时进行乳酸刺痛值评分。同时在入组前和入组第1d、第7d、第28d进行皮肤图像摄取（VISIA）、角质层含水量、经表皮水分丢失（TWEL）无创性客观定量检测，以及同一医生与患者对于皮损疗效的主观评价，记录不良反应。结果：入组34例敏感性皮肤患者，1例失访，3例因刺激反应退出，完成30例。30例患者入组时与出组时乳酸刺痛值在2.5min、5min以及两个时间段之和的总分均存在显著性差异（P<0.05）;医师主观皮损评分与患者主观皮损评分存在显著性差异（P<0.05）;其中有3例出现红斑、瘙痒及刺痛等刺激反应，发生率为8.82%，停止使用后缓解。结论：珀芙研舒缓保湿修护霜对于敏感性皮肤有一定的辅助治疗作用。

[关键词]敏感性皮肤;温泉水;乳酸刺痛值;无创性定量检测;主观评价

[中图分类号]R758.22   [文献标志码]A    [文章编号]1008-6455（2020）08-0049-03

Preliminary Observation on the Effect of Repairing Cream Containing Tibetan Thermal Spring Water on Sensitive Skin

WANG Qian，LI Yong，XIAN Yan，WANG Ying，WEN Xiang

（Department of Dermatology，West China Hospital，Sichuan University，Chengdu 610041，Sichuan，China）

Abstract： Objective To evaluate the effect and safety of repairing cream（trade name： Biorrier Anti-sensitive Repairing Cream ） containing Tibetan thermal spring water on sensitive skin. Methods Subjects used the Biorrier Anti-sensitive Repairing Cream once in the morning and evening for 28 days. Lactic acid stinging scores were noted before enrollment and at the end of the trial. Evaluations were performed before enrollment and on the 1st，7th，and 28th day of enrollment， including the skin image uptake （VISIA），stratum corneum hydration， and transepidermal water loss （TWEL），subjective evaluations of skin lesions and adverse reactions were recorded by the same doctor and patients. Results 34 patients were enrolled，1 patient was lost to follow-up， and 3 patients were withdrawn due to irritation and 30 patients completed the trail.There were statistically significant differences in the total scores of lactic acid stinging values between enrollment and the time of the last follow-up at 2.5 min， 5 min， and the sum of the two time periods（P<0.05）.There was significant difference between both patients' and doctor's subjective evaluations（P<0.05）.3 cases presented erythema， itching，tingling，the incidence rate was 8.82%， all relieved after discontinuation of use. Conclusion  Biorrier Anti-sensitive Repairing Cream has a certain adjuvant effect on sensitive skin.

Key words： sensitive skin;thermal spring water;lactic acid stinging test;non-invasive objective quantitative detection;subjective evaluation

近年來，随着环境的污染、生活压力增大、化妆品的不良使用等因素导致敏感性皮肤的发病率居高不下。根据2017中国敏感性皮肤诊治专家共识认为，敏感性皮肤是皮肤在生理或病理条件下的一种高反应状态，主要表现为易出现灼热、刺痛、瘙痒以及紧绷感等主观症状，伴或不伴红斑、鳞屑，毛细血管扩张等客观体征[1]。临床中治疗敏感性皮肤以抗炎、舒敏、保湿及修复为主。本试验主要观察了珀芙研舒缓保湿修护霜在敏感性皮肤屏障修复功能方面的辅助治疗作用，现将结果报道如下。

1  临床资料

1.1 一般资料：选择2019年7月-2019年8月四川大学华西医院皮肤性病科门诊临床诊断为激素依赖性皮炎、脂溢性皮炎、特应性皮炎及玫瑰痤疮患者共34例，均为女性，年龄21～41岁，所有患者临床表现为不同程度的红斑、干燥、瘙痒、灼热、刺痛、丘疹、鳞屑及皮肤紧绷感。……