卢湧湧 陶利萍 武志刚 张棋 蒋斌浩

[摘要] 目的 研究葡萄球菌核酸酶样结构蛋白1（SND1）在膀胱癌组织内的基因及蛋白表达，并探讨其临床意义。方法 对GEO数据库进行深入挖掘，观察SND1基因在膀胱癌中的表达，并分析其与患者临床信息及预后的关系;收集115例膀胱癌患者的临床预后资料，免疫组化法检测癌组织内SND1蛋白的表达，分析患者的临床预后与SND1蛋白之间的关系。 结果 115例GSE31684数据集中膀胱癌组织中SND1表达升高，且与患者的肿瘤大小、肿瘤分期、组织学类型、淋巴结转移相关，SND1高表达患者的总生存率及无复发生存率均低于SND1低表达患者。结论 在膀胱癌组织中SND1表达升高与患者预后不良相关，SND1可能是预测膀胱癌进程与预后的潜在分子标志物。

[关键词] SND1;膀胱癌;预后;总生存率;无复发生存率

[中图分类号] R737.14          [文献标识码] A          [文章编号] 1673-9701（2020）18-0005-04

Expression and clinical significance of SND1 in bladder cancer

LU Yongyong1   TAO Liping2   WU Zhigang1   ZHANG Qi1   JIANG Binhao1

1.Department of Urology，the First Affiliated Hospital of Wenzhou Medical University，Wenzhou   325000，China;2.Department of Gastroenterology，the First Affiliated Hospital of Wenzhou Medical University，Wenzhou   325000，China

[Abstract] Objective To study the gene and protein expression of staphylococcal nuclease domain-containing protein 1（SND1） in bladder cancer and to explore its clinical significance. Methods The GEO database was deeply mined. The expression of SND1 gene in bladder cancer was observed. Its relationship with clinical information and prognosis of patients was analyzed. The clinical prognostic data of 115 patients with bladder cancer were collected. SND1 in cancer tissues was detected by immunohistochemistry. The relationship between clinical prognosis and SND1 protein was analyzed. Results The expression of SND1 in bladder cancer tissue of 115 cases of GSE31684 data set was increased， and it was related to the tumor size， tumor stage， histological type， and lymph node metastasis. The overall survival rate and relapse-free survival rate of patients with high SND1 expression were lower than those with low expression of SND1. Conclusion The increased expression of SND1 in bladder cancer tissue is related to the poor prognosis of patients. SND1 may be a potential molecular marker to predict the progression and prognosis of bladder cancer.

[Key words] SND1;Bladder cancer;Prognosis;Overall survival rate;Relapse-free survival rate

膀胱尿路上皮癌（膀胱癌）是泌尿生殖系統发病率最高的恶性肿瘤之一[1]，据估计2012年全世界新增42.98万例膀胱癌患者，死亡165 100例[2]，在我国膀胱癌发病率呈上升趋势。尽管约75%的患者在最初诊断时为非肌浸润性膀胱癌，但在接受各种手术与辅助治疗后，有10%～30%的患者不仅复发而且发展为肌浸润性膀胱癌，在进一步接受复杂的根治性膀胱切除术和盆腔淋巴结清扫术后，约30%最终会发展为转移性疾病，这是造成多数膀胱癌患者肿瘤特异性死亡的主要原因[3-6]。因此，临床上迫切需要一种能够准确预测膀胱癌进程与预后的分子标志物，可以早期识别可能发展为肌浸润性膀胱癌的患者，实现早期诊断，改善预后[7]。……