刘国厚 陈德霞

[摘要] 目的 觀察复方甘草酸苷联合阿维A胶囊治疗银屑病的临床疗效。 方法 选择2018年3月～2019年3月我院治疗的银屑病患者60例，随机分为两组，每组各30例，对照组予阿维A胶囊每次10 mg口服， 2次/d，连用2个月。观察组在对照组治疗基础上联合复方甘草酸苷治疗，25 mg/片，每次2片， 3次/d，连用2个月。治疗后对比分析两组的临床疗效、两组患者治疗前后的皮损面积和严重程度评分及不良反应发生情况。 结果 观察组30例患者，无效1例，有效率达96.67%;对照组30例患者，无效9例，有效率达70.00%。两组疗效对比显示，观察组的总有效率明显高于对照组（P<0.05）。观察组和对照组患者治疗前的皮损面积和严重程度评分比较，差异不显著（P>0.05）。治疗后，观察组和对照组患者的皮损面积和严重程度评分比较，分别显著低于治疗前，且观察组患者治疗后的皮损面积和严重程度评分仅（4.86±1.23）分，显著低于对照组的（8.11±2.64）分，两组比较差异具有显著性（P<0.05）。 观察组出现口干2例，眼干2例，皮肤干燥1例，不良反应发生率为 16.67%;对照组出现口干3例，眼干3例，皮肤干燥2例，脱发2例，血脂增高1例，不良反应发生率为 36.67%，观察组明显低于对照组，差异有统计学意义（P<0.05）。 结论 复方甘草酸苷联合阿维A胶囊治疗银屑病临床疗效确切，安全性好，且可以明显改善患者的临床症状，值得临床推广和应用。

[关键词] 银屑病;复方甘草酸苷;阿维A胶囊;不良反应

[中图分类号] R751          [文献标识码] B          [文章编号] 1673-9701（2020）17-0105-03

Observation of clinical efficacy of compound glycyrrhizin combined with acitretin capsules in treatment of psoriasis

LIU Guohou1   CHEN Dexia2

1.Department of Dermatology， Taishan Hospital of Shandong Province， Tai'an   271000， China; 2.Department of Rheumatology， Tai'an Hospital of TCM in Shandong Province， Tai'an   271000， China

[Abstract] Objective To observe the clinical efficacy of compound glycyrrhizin combined with acitretin capsules in the treatment of psoriasis. Methods 60 patients with psoriasis who were treated in our hospital from March 2018 to March 2019 were selected and randomly divided into two groups， with 30 patients in each group. The control group was orally given acitretin capsules 10 mg per dose， twice a day for two months. The observation group， on the basis of the treatment of the control group， was further given compound glycyrrhizin 25 mg per tablet， two tablets per dose， three times a day for two months. After treatment， the clinical efficacy was compared and analyzed between the two groups after treatment， the area of skin lesion and severity scores before and after treatment were analyzed and compared between the two groups and adverse reactions. Results Of the 30 patients in the observation group， one was ineffective， and the effective rate was 96.67%; of the 30 patients in the control group， nine were ineffective， and the effective rate was 70.00%. The comparison of the curative effect between the two groups showed that the total effective rate in the observation group was significantly higher than that in the control group（P<0.05）. There was no significant difference in the lesion area and severity score between the observation group and the control group before treatment （P>0.05）. After treatment， the lesion area and severity scores were compared between the observation group and the control group， and the data were significantly lower than those before treatment. Moreover， the skin lesion area and severity score after treatment in the observation group were only 4.86±1.23， which was significantly lower than 8.11±2.64 in the the control group， and the difference between the two groups was significant（P<0.05）. In the observation group， there were two cases of dry mouth， two cases of dry eyes， one case of dry skin， and the incidence of adverse reactions was 16.67%; in the control group， there were three cases of dry mouth， three cases of dry eyes， two cases of dry skin， two cases of hair loss， one case of increased blood lipid， and the incidence of adverse reactions was 36.67%. The observation group was significantly lower than the control group， and the difference was statistically significant（P<0.05）. Conclusion The compound glycyrrhizin combined with acitretin capsules has an exact clinical efficacy on psoriasis with a good safety， which can significantly improve the clinical symptoms of patients and is worthy of clinical promotion and application.

[Key words] Psoriasis; Compound glycyrrhizin; Acitretin capsules; Adverse reactions

银屑病是一种常见的慢性复发性炎症性皮肤病，病程长、治愈难。研究证实，银屑病的发病与机体免疫力降低、补体功能异常等有关[1]。目前治疗银屑病的药物种类较多，但仍主要以免疫抑制药物及糖皮质激素药物治疗为主[2]。本研究旨在探讨复方甘草酸苷联合阿维A胶囊治疗银屑病的疗效，现报道如下。

1 资料与方法

1.1 一般资料

选择2018年3月～2019年3月我院治疗的银屑病患者60例，随机分为两组，其中观察组30例，男18例，女12例;年龄19～71岁，平均（41.3±5.1）岁;病程（5.23±1.13）年，皮损类型：点滴状6例，钱币状8例，地图状11例，混合状5例。……