刘振亮

[摘要] 目的 探究螺內酯联合贝前列素钠治疗2型糖尿病肾病患者的疗效及对患者肾功能的影响。 方法 选取2018年7月—2019年7月间该院收治的80例糖尿病肾病患者作为研究对象，随机分为对照组和观察组，均为40例。对照组单纯螺内酯治疗，观察组在对照组基础上联合贝前列素钠治疗。观察两组患者的血压指标、肾功能指标、血流变指标以及临床治疗疗效。 结果 治疗前两组患者的血压水平对比差异无统计学意义（P>0.05）;治疗后观察组患者的血压水平显著低于对照组（P<0.05）。治疗前两组患者的肾功能指标SCr、BUN以及24 h尿蛋白水平对比差异无统计学意义（P>0.05）;治疗后观察组患者的SCr、BUN以及24 h尿蛋白水平低于对照组，差异有统计学意义（P<0.05）。治疗前两组患者的血流变指标对比差异有统计学意义（P>0.05）;治疗后观察组患者的血流变指标全血比黏度、血浆比黏度、全血比还原粘度低于对照组，差异有统计学意义（P<0.05）。观察组的治疗总有效率高于对照组（P<0.05）。 结论 螺内酯联合贝前列素钠治疗糖尿病肾病的效果显著，可降低患者的血压、血液黏度，改善患者的肾功能。

[关键词] 糖尿病肾病;螺内酯;贝前列素钠;肾功能;血液黏度

[中图分类号] R587          [文献标识码] A          [文章编号] 1672-4062（2020）05（b）-0188-03

Effects of Spironolactone Combined with Prostaglandin Sodium on Renal Function in Patients with Type 2 Diabetic Nephropathy

LIU Zhen-liang

Department of Pharmacy， Pingdu Second People's Hospital， Pingdu， Shandong Province， 266731 China

[Abstract] Objective To investigate the effect of spironolactone combined with beprostone sodium on patients with type 2 diabetic nephropathy and its effect on renal function. Methods A total of 80 patients with diabetic nephropathy admitted in the hospital from July 2018 to July 2019 were selected as the research objects and randomly divided into control group and observation group， both of which were 40 cases. The control group was treated with spironolactone alone， and the observation group was treated with beprost sodium in combination with the control group. Observe the blood pressure index， renal function index， hemorheology index and clinical treatment effect of the two groups of patients. Results There was no statistically  significant difference in blood pressure levels between the two groups of patients before treatment （P>0.05）; the blood pressure levels of patients in the observation group were significantly lower than those in the control group after treatment （P<0.05）. The renal function indicators SCr， BUN， and 24 h urine protein levels of the two groups of patients before treatment were not statistically significant （P>0.05）. The levels of SCr， BUN， and 24 h urine protein of the observation group were lower than those of the control group after treatment， the difference was statistically significance（P<0.05）. There was no statistically significant difference in hemorheological indexes between the two groups of patients before treatment （P>0.05）. After treatment， the blood rheological indexes of the observation group were lower than that of the control group， statistical significance （P<0.05）. The total effective rate in the observation group was higher than that in the control group （P<0.05）， which was statistically significant. Conclusion Spironolactone combined with beprostone sodium has a significant effect on diabetic nephropathy， which can reduce blood pressure and blood viscosity of patients and improve renal function of patients.

[Key words] Diabetic nephropathy; Spironolactone; Bereprost sodium; Renal function; Blood viscosity

糖尿病肾病是糖尿病患者随着疾病发展并发的一种严重并发症。其发病机理为长期高血糖状态会损伤血管内皮，导致肾小球硬化，继而对肾功能造成影响，最终并发糖尿病肾病[1]。糖尿病肾病随着疾病进展可发展为尿毒症，威胁患者的生命安全和生存質量。因此治疗糖尿病肾病一致是临床极为重视的疾病，通过不断研究发现早期对糖尿病肾病进行治疗干预，可显著改善患者的预后。该次研究以该院于2018年7月—2019年7月收治的80例患者为例，主要是对螺内酯与贝前列素钠在糖尿病肾病中的疗效进行临床验证，因此选取我院收治的部分患者作为研究对象，取得了较好的应用效果，现报道如下。