刘国厚 陈德霞

[摘要] 目的 探討卡介菌多糖核酸联合玉屏风颗粒治疗慢性荨麻疹的疗效。 方法 选取2018年1月～2019年1月我院治疗的慢性荨麻疹患者80例作为研究对象，随机分为观察组、对照组，每组各40例，其中对照组予卡介菌多糖核酸治疗，观察组联合玉屏风颗粒治疗，治疗后对比分析两组患者的临床疗效及临床症状评分治疗前后的变化情况。 结果 观察组患者与对照组患者治疗后的总有效率分别为97.5%、70.0%，两组总有效率比较，差异有统计学意义（P<0.05）。治疗前，观察组和对照组患者的各项临床症状分别比较，差异无统计学意义（P>0.05）。治疗后，观察组和对照组患者的各项临床症状评分比较，差异有统计学意义（P<0.05），观察组患者的各项临床症状评分分别显著低于对照组（P<0.05）。 结论 卡介菌多糖核酸、玉屏风颗粒两种药物联合应用治疗慢性荨麻疹可以显著提高临床疗效，且患者的各种临床症状均明显得到改善，值得广泛推广和应用。

[关键词] 慢性荨麻疹;卡介菌多糖核酸;玉屏风颗粒;临床症状

[中图分类号] R758.24          [文献标识码] B          [文章编号] 1673-9701（2020）16-0100-03

Observation on the curative effect of BCG polysaccharide nucleic acid combined with yupingfeng granules in the treatment of chronic urticaria

LIU Guohou1   CHEN Dexia2

1.Department of Dermatology， Taishan Hospital of Shandong Province， Taian   271000， China; 2.Department of Rheumatology， Taian Hospital of TCM， Taian   271000， China

[Abstract] Objective To explore the curative effect of BCG polysaccharide nucleic acid combined with Yupingfeng granules on chronic urticaria. Methods From January 2018 to January 2019， 80 patients with chronic urticaria who were treated in our hospital were selected as the study subjects， and they were randomly divided into an observation group and a control group， with 40 cases in each group. The control group was treated with BCG polysaccharide nucleic acid， and the observation group was further given Yupingfeng granules for combined treatment. After treatment， the clinical efficacy was compared and analyzed between the two groups， and the changes of clinical symptom scores before and after treatment were compared and analyzed between the two groups of patients. Results The total effective rate in the observation group and the control group after treatment was 97.5% and 70.0% respectively， and there was a significant difference in the total effective rate between the two groups（P<0.05）. Before treatment， the clinical symptoms in the observation group and the control group were compared， and the differences were not statistically significant（P>0.05）. After treatment， the clinical symptom scores in the observation group and the control group were compared， and the differences were statistically significant（P<0.05）. The clinical symptom scores in the patients in the observation group were significantly lower than those in the control group（P<0.05）. Conclusion The combined application of BCG polysaccharide nucleic acid and Yupingfeng granules in the treatment of chronic urticaria can significantly improve the clinical efficacy， and the patients' clinical symptoms have been significantly improved， which is worthy of widespread promotion and application.

[Key words] Chronic urticaria; BCG polysaccharide nucleic acid; Yupingfeng granules; Clinical symptoms

慢性荨麻疹（Chronic urticaria，CU）是皮肤科的常见病、多发病，以风团与血管性水肿为主要临床表现，伴瘙痒烧灼感，严重者可伴发热和头痛等症状[1]。慢性荨麻疹发病机制和病因较复杂，常反复发作，缺乏特异性的治疗方法且临床难以彻底治愈[2]。荨麻疹的发病机制较复杂，目前认为主要是由免疫和炎症性反应所致[3]。以往临床治疗慢性荨麻疹主要应用组胺药物等，虽可控制患者的症状，然而停药后复发率较高[4]。研究证实，卡介菌多糖核酸从卡介菌中提取，通过多种免疫调节功能对慢性荨麻疹起到治疗效果[5]。玉屏风颗粒辅助治疗慢性荨麻疹可显著提高患者的免疫力[6]。本研究旨在探讨卡介菌多糖核酸、玉屏风颗粒二者联合应用治疗慢性荨麻疹的疗效，现报道如下。……