精神分裂症患者血清尿酸水平分析
2019-11-22梁美妹
梁美妹


[摘要] 目的 分析精神分裂症患者血清尿酸水平。方法 入选2018年1月—2019年1月的精神分裂症患者120例,视为观察组,另外选择同一时间来该院健康体检者120名,视为对照组,通过对两组的血清尿酸水平进行测定,分析精神分裂症患者的血清尿酸变化情况。结果 观察组的血清尿酸水平(385.74±60.02)μmol/L明显高于对照组(206.72±10.38)μmol/L,差异有统计学的意义(t=86.428,P<0.05)。观察组中病程超过30年的患者的血清尿酸水平(405.27±60.34)μmol/L明显高于病程小于10年的患者的血清尿酸水平(294.57±30.69)μmol/L,差异有统计学的意义(P<0.05)。男性患者的血清尿酸水平(387.15±57.15)μmol/L明显高于女性患者(269.84±41.25)μmol/L,差異有统计学的意义(t=54.622,P<0.05)。结论 精神分裂症患者的血尿酸水平有明显的增高,男性患者的血尿酸水平较高,病程越长的患者的血尿酸水平越高。
[关键词] 精神分裂症;血清尿酸;水平分析
[中图分类号] R74 [文献标识码] A [文章编号] 1674-0742(2019)08(c)-0192-03
[Abstract] Objective To analyze serum uric acid levels in patients with schizophrenia. Methods A total of 120 patients with schizophrenia from January 2018 to January 2019 were enrolled in the observation group. In addition, 120 patients who were admitted to our hospital at the same time were selected as the control group. The serum uric acid levels were measured to analyze changes in serum uric acid in patients with schizophrenia. Results The serum uric acid level (385.74±60.02) μmol/L in the observation group was significantly higher than that in the control group (206.72±10.38) μmol/L. The difference was statistically significant (t=86.428, P<0.05). Serum uric acid levels (405.27±60.34) μmol/L in patients with more than 30 years duration of disease in the observation group were significantly higher than those in patients with less than 10 years course of the disease (294.57±30.69) μmol/L, the difference was statistically significant (P<0.05). The serum uric acid level (387.15±57.15) μmol/L was significantly higher in male patients than in female patients (269.84±41.25) μmol/L, and the difference was statistically significant (t=54.622, P<0.05). Conclusion The serum uric acid level of patients with schizophrenia is significantly increased. The blood uric acid level of male patients is higher. The longer the course of the disease, the higher the blood uric acid level.
[Key words] Schizophrenia; Serum uric acid; Level analysis
精神分裂症是一组严重的精神性疾病,常见的病因包括自身的性格和外界的刺激等,但是具体的病因并不明确,发病后患者可出现思维、感知、行为和情感等多个方面的功能的障碍,一般患者的意识清楚,智力不受影响,但是会出现认知功能的损伤,病情容易反复发病,多次发作后会出现病情的加重与恶化,患者很容易出现精神衰退等,因为患者存在精神分裂症,对机体的健康存在一定的影响,有文献报道,精神分裂症患者的代谢功能可能存在异常,患者会出现血清尿酸水平异常表现,尿酸是嘌呤核苷酸的代谢最终的产物,可以清除体内的自由基起到抗氧化的作用,但是高尿酸血症容易造成患者的肾脏的损伤,直接影响患者的身体健康[1-5]。因此,分析精神分裂症患者的血清尿酸水平的变化对疾病的治疗有一定的促进作用,该研究选取该院于2018年1月—2019年1月收治的120例患者为研究对象,比较了精神分裂症患者与健康者的血清尿酸水平及不同性别和病程的患者的血清尿酸水平的变化情况。……
