陈丽吉

[摘要] 目的 探讨六味地黄丸加减中药膏方治疗肝肾阴虚型帕金森病的效果，并对其评价。方法 方便选择该院自2015年1月—2018年11月期间收治的肝肾阴虚型帕金森病患者80例，利用奇偶数分组法将其分成对照组与治疗组，每组40例，对照组进行多巴丝肼片，治疗组在对照组方法的基础上给予六味地黄丸加减中药膏方进行治疗，观察并对比两组患儿的治疗效果。 结果 通过对两组患者施以不同的治疗方法可知，治疗组的总有效率92.5%，明显高于对照组的65.0%，差异有统计学意义（χ2=9.03，P=0.00）;且治疗组UPDRS为（18.76±5.11）分、PDSS为（121.72±13.99）分、SCOPA-AUT为（21.83±2.27）分，明显优于对照组的（29.22±6.28）分、（97.06±12.68）分、（28.14±3.29）分，各项数据对比差异有统计学意义（t=8.17，P=0.00;t=8.26，P=0.00;t=9.98，P=0.00）。 结论 在肝肾阴虚型帕金森疾病的治疗过程中，在常规治疗的基础上联合六味地黄丸加减中药膏方，能够改善患者临床症状，提高治疗效果，值得在临床上广泛应用推广。

[关键词] 六味地黄丸加减;中药膏方;肝肾阴虚型;帕金森

[中图分类号] R277.7          [文献标识码] A          [文章编号] 1674-0742（2019）08（c）-0176-03

[Abstract] Objective To investigate the effect of Liuwei Dihuang Pills in the treatment of Parkinson's disease of liver and kidney yin deficiency. Methods Convenient selected eighty patients with Parkinson's disease of liver and kidney yin deficiency were enrolled in our hospital from January 2015 to November 2018. They were divided into control group and treatment group by even and odd group method， 40 cases in each group. The treatment group was treated with Liuwei Dihuang Pills plus or minus traditional Chinese medicine ointment on the basis of the control group. The therapeutic effects of the two groups were observed and compared. Results By applying different treatment methods to the two groups of patients， the total effective rate of the treatment group was 92.5%， which was significantly higher than that of the control group （65.0%）. The difference was significant （χ2=9.03， P=0.00）; and the UPDRS of the treatment group was （18.76±5.11）points， the PDSS was （121.72±13.99）points， and the SCOPA-AUT was（21.83±2.27）points， which was significantly better than the control group （29.22±6.28）points，（97.06±12.68）points，（28.14±3.29）points， the data were significantly different which was statistically significant （t=8.17， P=0.00; t=8.26， P=0.00; t=9.98， P=0.00）. Conclusion In the treatment of Parkinson's disease with liver and kidney yin deficiency， combined with Liuwei Dihuang Pill can reduce the clinical symptoms and improve the therapeutic effect on the basis of conventional treatment. It is worthy of widespread application in clinical practice.

[Key words] Liuwei Dihuang Pills addition and subtraction; Chinese medicine cream; Liver and kidney yin deficiency; Parkinson

帕金森病屬于中枢神经系统中的一种变性疾病，是中老年中较为常见的疾病，其临床症状一震颤、动摇、强直以及运动迟缓与姿势障碍等情况为特点，患者在患得此病后逐渐的丧失生活自理能力，不仅对患者的身心与生活质量产生严重的影响，在一定程度上还会增加家庭的负担[1]。帕金森病在中医范围内属于颤证，根据相关资料记载，1992年的中华全国中医学会老年医学会中就公布了《中医老年颤证诊断和疗效评定标准》，此标准将颤证分为4种类型，而据数据表明关于帕金森疾病在中医证候的分型中，肝肾阴虚型帕金森疾病的占比较多，是临床上较为常见的证候类型[2]。……