谢海霞　王雪燕　杨晓燕

摘要：目的  比較欣普贝生和缩宫素对足月胎膜早破的临床效果。方法  选择我院2017年12月～2018年5月收治的胎膜早破孕妇200例，其中92例孕妇放置欣普贝生引产的作为欣普贝生组，缩宫素引产的108例孕妇作为缩宫素组，比较两组孕妇用药后引产结局，包括宫颈评分、破膜至用药时间、用药至临产时间、总产程、引产成功率、剖宫产率、产后出血及新生儿结局。结果  两组产后2 h出血量比较，差异无统计学意义（P>0.05）;欣普贝生组引产前宫颈评分低于缩宫素组，用药至临产时间及总产程少于缩宫素组，差异有统计学意义（P<0.05）;欣普贝生组、缩宫素组引产成功率分别为81.52%和83.33%，绒毛膜羊膜炎率分别3.26%、3.70%，差异均无统计学意义（P>0.05）;两组新生儿窒息、羊水粪染及胎儿窘迫发生率比较，差异无统计学意义（P>0.05）。结论  针对足月胎膜早破，宫颈不成熟的孕妇，欣普贝生诱发宫缩快，宫缩强而协调，是安全有效的引产方式，其剖宫产率、新生儿不良结局、产后出血与使用缩宫素基本一致，不增加风险。

关键词：催产素;胎膜早破;前列腺素E2

中图分类号：R719.3                                文献标识码：A                                  DOI：10.3969/j.issn.1006-1959.2019.14.047

文章编号：1006-1959（2019）14-0144-03

Abstract：Objective  To compare the clinical effects of pingpubeisheng and oxytocin on premature rupture of fetal membranes. Methods  We selected 200 pregnant women with premature rupture of fetal membranes from December 2017 to May 2018 in our hospital. Among them， 92 pregnant women were placed in the Xinpubeisheng group， and 108 pregnant women induced by oxytocin were used as the contraction. In the Miyasu group， the results of induction of labor were compared between the two groups of pregnant women， including cervical score， rupture of the membrane to medication， medication to labor， total labor， induction of labor， cesarean section rate， postpartum hemorrhage and neonatal outcome.Results  There was no significant difference in the amount of 2h postpartum hemorrhage between the two groups （P>0.05）. The cerebral score of the Xinpubeisheng group before induction of labor was lower than that of the oxytocin group. The time from the drug to the labor and the total labor were less than the oxytocin group， the difference was statistically significant （P<0.05）. The success rate of induction of labor in Xinpubeisheng group and oxytocin group was 81.52% and 83.33%， respectively. The rate of chorioamnionitis was 3.26% and 3.70%， respectively，the difference was not statistically significant（P>0.05）; There was no significant difference in the incidence of neonatal asphyxia， amniotic fluid fecal infection and fetal distress between the two groups （P>0.05）.Conclusion  For pregnant women with premature rupture of fetal membranes and immature cervical cervix， Xinpubeisheng induces rapid contraction and strong contraction of uterine contractions. It is a safe and effective method of induction of labor， cesarean section rate， neonatal adverse outcome， postpartum hemorrhage; it is basically consistent with the use of oxytocin without increasing the risk.

Key words：Oxytocin;Premature rupture of fetal membranes;Prostaglandin E2

胎膜早破（premature rupture of fetal membranes）是围生期最常见的并发症，可导致围生儿病死率、宫内感染率及产褥感染率增加[1]。孕妇在发生胎膜早破后其阴道内的病原微生物可发生上行感染，导致宫内感染。孕妇发生胎膜早破的时间若超过24 h，其发生相关感染的几率可增加5～10倍[2]。为减少感染机会，防止母婴并发症，对足月胎膜早破2 h未临产的孕妇引产[3]。小剂量催产素作为一种安全有效的引产方法，广泛应用于临床，但其促宫颈成熟慢、时间长。地诺前列……