李江

【摘要】 目的：探讨血清胃蛋白酶原（PG）联合靛胭脂染色诊断早期胃癌的价值。方法：选择2018年3月-2019年3月在笔者所在医院诊治的42例消化道症状患者为研究对象，并将其随机均分为观察组及对照组，各21例。同时选择同一时期来院参检的21例健康体检人员，将其设为健康组，三组均取空腹静脉血进行血清PGⅠ、PGⅡ、PGⅠ/PGⅡ的测定，观察组在此基础上联合靛胭脂染色诊断。对比三组的PGⅠ、PGⅡ、PGⅠ/PGⅡ水平，以及观察组及对照组的检出率。结果：在血清胃蛋白酶原检测中，观察组及对照组的PGⅠ、PGⅠ/PGⅡ水平均低于健康组，PGⅡ高于健康组，三组比较差异有统计学意义（P<0.05），但观察组与对照组比较，差异无统计学意义（P>0.05）。观察组的阳性检出率高于对照组，差异有统计学意义（P<0.05）。结论：通过血清胃蛋白酶原检测，有助于胃癌筛查，而在此基础上联合靛胭脂染色检测，则能够提升早期胃癌的检出率，可为临床进一步治疗提供有效依据。

【关键词】 血清胃蛋白酶原; 靛胭脂染色; 早期胃癌; 胃蛋白酶原Ⅰ; 胃蛋白酶原Ⅱ; 胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ

doi：10.14033/j.cnki.cfmr.2019.16.029 文献标识码 B 文章编号 1674-6805（2019）16-00-02

【Abstract】 Objective：To investigate the value of serum pepsinogen combined with rouge staining in the diagnosis of early gastric cancer.Method：Forty-two patients with gastrointestinal symptoms who were treated in our hospital from March 2018 to March 2019 were enrolled as the study subjects.They were randomly divided into the observation group and the control group，21 cases in each group.At the same time，21 healthy physical examination personnel who came to the hospital during the same period were selected as the healthy group.All the three groups were treated with fasting venous blood for serum PGI，PGⅡ，PGI/PGⅡ，and the observation group was further diagnosed by combined rouge staining..The PGI，PGⅡ，PGI/PGⅡ levels of the three groups were compared，as well as the detection rates of the observation group and the control group.Result：In the serum pepsinogen test，the PGI and PGI/PGⅡ levels in the observation group and the control group were lower than those in the healthy group，and the PGⅡ was higher than the healthy group，there were significant differences among the three groups，which were statistically significant（P<0.05）.There was no significant difference between the observation group and the control group（P>0.05）.The positive detection rate of the observation group was higher than that of the control group，the difference was statistically significant（P<0.05）.Conclusion：Serum pepsinogen detection is helpful for gastric cancer screening.On the basis of this，combined with rouge staining detection can improve the detection rate of early gastric cancer，which can provide an effective basis for further clinical treatment.

【Key words】 Serum pepsinogen; Rouge staining; Early gastric cancer; PGⅠ; PGⅡ; PGI/PGⅡ

First-authors address：Jingzhou Third Peoples Hospital，Jingzhou 434001，China

胃癌屬于临床中一种常见的消化道恶性肿瘤，此病症早期诊断的概率较低，且死亡率较高，当前胃癌的确诊主要以组织病理学的检测为主[1]，但对于早期胃癌及癌前病变而言，普通内镜检查在特异性表现方面比较缺乏，故容易出现漏诊，使患者失去最佳治疗机会。胃蛋白酶原（PG）属于胃蛋白酶前体，主要分为PGⅠ和PGⅡ两种亚型，以往研究人员利用PGⅠ、PGⅡ以及PGⅠ/PGⅡ对患者胃黏膜功能及状态进行检测，且近年来这种血清胃蛋白酶原检测在胃癌筛查中的应用越来越普遍，而内镜下靛胭脂染色检测可将异常病变的胃黏膜进行有效识别[2]，为研究早期胃癌的有效诊断方法，本次研究在2018年3月-2019年3月共选择42例消化道症状患者及21例健康参检人员作为研究对象，并对血清胃蛋白酶原联合靛胭脂染色的诊断效果加以分析，现报道如下。……