叶丽芳 林响 曹时珍

【摘要】 目的：探讨射干麻黄汤联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床效果。方法：选取笔者所在医院2018年1月-2019年1月儿科收治的42例咳嗽变异性哮喘患儿为研究对象。按照治疗方式的不同将其分为对照组和研究组，每组21例。对照组给予孟鲁司特钠治疗，研究组给予孟鲁司特钠+射干麻黄汤治疗。比较两组临床疗效。结果：研究组治疗总有效率为95.2%，高于对照组的71.4%，差异有统计学意义（P<0.05）。研究组咳嗽症状评分明显低于对照组，差异有统计学意义（P<0.05）。研究组治疗后各肺功能指标均优于对照组，差异有统计学意义（P<0.05）。研究组患儿症状缓解及完全消退时间均较对照组短，差异有统计学意义（P<0.05）。结论：对咳嗽变异性哮喘患儿采取射干麻黄汤联合孟鲁司特钠治疗的临床效果显著，能够有效改善患儿临床症状，缩短疾病恢复时间。

【关键词】 射干麻黄汤 孟鲁司特钠 咳嗽变异性哮喘 疗效 中医症候

doi：10.14033/j.cnki.cfmr.2019.29.073 文献标识码 B 文章编号 1674-6805（2019）29-0-03

[Abstract] Objective： To explore the clinical effect of Shegan Mahuang Decoction combined with Montelukast Sodium in the treatment of cough variant asthma in children. Method： A total of 42 children with cough variant asthma admitted in our hospital from January 2018 to January 2019 were selected as the study subjects. According to the different treatment methods， they were divided into the control group and the study group， 21 cases in each group. The control group was treated with Montelukast Sodium， while the study group was treated with Montelukast Sodium combined with Shegan Mahuang Decoction. The clinical efficacy of the two groups was compared. Result： The total effective rate of the study group was 95.2%， which was higher than 71.4% of the control group， the difference was statistically significant （P<0.05）. The cough symptom score of the study group was significantly lower than that of the control group， the difference was statistically significant （P<0.05）. The pulmonary function indexes in the study group were better than those in the control group after treatment， and the differences were statistically significant （P<0.05）. The time of remission and complete remission of symptoms in the study group were shorter than those in the control group， and the differences were statistically significant （P<0.05）. Conclusion： The clinical effect of Shegan Mahuang Decoction combined with Montelukast Sodium in children with cough variant asthma is significant， which can effectively improve the clinical symptoms of children and shorten the recovery time of the disease.

[Key words] Shegan Mahuang Decoction Montelukast Sodium Cough variant asthma Efficacy TCM symptom

First-authors address： Fuzhou Second Hospital Affiliated to Xiamen University， Fuzhou 350007， China

咳嗽變异性哮喘是一种主要因炎性物质引发的慢性哮喘疾病，临床症状主要以干咳、憋闷、呼吸困难等为主[1]。该疾病具有慢性发作的特点，症状鉴别度较低，与常规的上呼吸道疾病症状有较高的相似性。西医领域中常采取头孢类抗生素及白三烯受体拮抗剂等药物联合治疗，但若长期使用此类药物，能够增强抗生素耐药性，且副作用较多，安全性较差。在孟鲁司特钠基础上联合使用中医汤剂具有较高的实用意义。鉴于此，特选取收治的42例咳嗽变异性哮喘患儿展开研究，现报道如下。

为证明射干麻黄汤联合孟鲁司特钠在临床上的应用效果，选取笔者所在医院2018年1月-2019年1月儿科收治的42例咳嗽变异性哮喘患儿展开研究，结果显示，研究组患儿治疗总有效率为95.2%，高于对照组71.4%（P<0.05）;研究组咳嗽症状评分明显低于对照组（P<0.05）;研究组患儿各肺功能指标均优于对照组（P<0.05）;研究组患儿症状缓解及完全消退时间均较对照组短（P<0.05）。说明咳嗽变异性哮喘患儿采取射干麻黄汤联合孟鲁司特钠的治疗效果较单纯使用孟鲁司特钠的效果更加显著。

综上所述，对咳嗽变异性哮喘患儿采取射干麻黄汤联合孟鲁司特钠治疗的临床效果显著，能够有效改善患儿临床症状，缩短疾病恢复时间。……