陈丽 丁金琴

【摘要】 目的：探討对非小细胞肺癌患者行再程放疗+化疗进行治疗的临床效果。方法：抽取笔者所在医院在2011年6月-2015年12月所收治的58例非小细胞肺癌患者作为本次试验的研究主体，将其按照所采取的治疗方式不同分为放疗组和放化疗组，每组29例患者。放疗组仅行单一的再程放疗，放化疗组行再程放疗联合化疗，观察并对比两组治疗效果、不良反应发生率及复发率。结果：放化疗组的治疗有效率51.72%（15/29），放疗组为20.69%（6/29），放化疗组的治疗有效率显著高于放疗组，两组差异有统计学意义（P<0.05）。放化疗组的不良反应发生率75.86%（22/29），与放疗组的55.17%（16/29）相比，差异无统计学意义（P>0.05）。放化疗组复发10例（34.48%），显著少于放疗组的16例（55.17%），两组差异有统计学意义（P<0.05）。结论：对非小细胞肺癌患者行再程放疗+化疗进行联合治疗，治疗效果相对较为理想，虽然不良反应的发生率相对较高，但是对于患者而言可以忍受。

【关键词】 再程放疗 化疗 非小细胞肺癌患者

doi：10.14033/j.cnki.cfmr.2019.29.021 文献标识码 B 文章编号 1674-6805（2019）29-00-03

[Abstract] Objective： To investigate the clinical effect of recurrent radiotherapy + chemotherapy for patients with non-small cell lung cancer. Method： A total of 58 patients with non-small cell lung cancer who were admitted to the hospital from June 2011 to December 2015 were selected as the main subjects of the study. They were divided into radiotherapy group and radiotherapy and chemotherapy group according to the different treatment methods. 29 patients in each group. In the radiotherapy group， only a single re-radiation therapy was performed. The radiotherapy and chemotherapy group received re-radiation combined with chemotherapy. The therapeutic effects， adverse reaction rate and recurrence rate were observed and compared. Result： The effective rate of treatment in the radiotherapy and chemotherapy group was 51.72% （15/29）， and that in the radiotherapy group was 20.69% （6/29）. The effective rate of the radiotherapy and chemotherapy group was significantly higher than that in the radiotherapy group. The difference between the two groups was statistically significant （P<0.05）. The incidence of adverse reactions in the radiotherapy and chemotherapy group was 75.86% （22/29） compared with 55.17% （16/29） in the radiotherapy group， and the difference was not statistically significant （P>0.05）. There were 10 cases （34.48%） with recurrence in the radiotherapy and chemotherapy group， which was significantly less than 16 cases （55.17%） in the radiotherapy group. The difference was statistically significant （P<0.05）. Conclusion： For patients with non-small cell lung cancer who underwent combined recurrent radiotherapy plus chemotherapy， the treatment effect is relatively ideal. Although the incidence of adverse reactions is relatively high， it can be tolerated for patients.

[Key words] Recurrent radiotherapy Chemotherapy Patients with non-small cell lung cancer

First-authors address： The 95th Hospital of the Chinese Peoples Liberation Army， Putian 351100， China

近年来，我国城市的发展逐渐加快，加之老龄化趋势的不断加剧，人们受到周围环境、吸烟习惯等因素的影响，肺癌的发病率大大增加，肺癌已经成为严重危害人们身体健康的公共卫生問题之一，肺癌一旦发生，具有较高的死亡率，将会严重影响人们的生命安全。在过去的30年里我国发生肺癌发病率每年以26.9%的速度逐渐增加，肺癌死亡率增加465%，与全球水平相比相对更高[1]。其中，非小细胞肺癌的发生概率占据肺癌患者的80%～85%，目前，临床上对于非小细胞肺癌患者通过采取化疗及放疗的方式进行治疗，虽然能够达到一定的治疗效果，但是大部分患者可能出现局部或者远处转移的情况，并不利于患者的预后[2]。因此，本文研究抽取笔者所在医院在2011年6月-2015年12月所收治的58例非小细胞肺癌患者，通过行再程放疗及化疗的方法进行治疗，能够达到一定的治疗效果，具体研究得出结论如下所示。……