刘建成

[摘要] 目的 探析該地区学龄儿童（5周岁）幽门螺杆菌感染状况，并对其危险因素进行分析。方法 方便抽取2016年1月—2017年12月期间，5周岁入园体检儿童500例作为该次的研究对象，其中后龙卫生院210例，区妇幼保健院290例。对所有儿童进行血清Hp-IgG检测，并对所有研究对象的家长进行问卷调查。其中血清检测结果为阳性的为病例组，结果为阴性的为对照组。结果 该次研究的500例学龄儿童中，有83例儿童的血清Hp-IgG检测结果呈阳性，阳性率为16.6%，其余417例为阴性，阴性率为83.4%。通过问卷调查学龄儿童相关的生活方式，并通过单因素χ2分析、多因素Logistic回归分析发现，影响学龄儿童感染幽门螺杆菌的主要危险因素包括父母Hp-IgG阳性（OR=2.384，CI：1.365～1.881，P=0.01）、爱啃手指（OR=3.019，CI：2.014～4.362，P=0.01）、与父母公用餐具或牙具（OR=3.375，CI：2.833～4.018，P=0.000）以及年龄（OR=3.788，CI：2.035～3.980，P=0.000）。结论 学龄儿童幽门螺杆菌感染率比较高，应积极预防或诊治幽门螺杆菌感染，加强宣教，增强儿童的卫生意识，养成良好的生活习惯对于预防幽门螺杆菌的感染具有非常重要的意义。

[关键词] 学龄儿童;幽门螺杆菌;危险因素

[中图分类号] R725.7          [文献标识码] A          [文章编号] 1674-0742（2018）08（c）-0074-03

Investigation of Helicobacter Pylori Infection in School-aged Children and Analysis of Its Risk Factors

LIU Jian-cheng

Department of Clinical Laboratory， Quanzhou Center for Disease Control and Prevention， Quanzhou， Fujian Province， 362802 China

[Abstract] Objective To analyze the status of Helicobacter pylori infection in school-aged children （age 5 years old） in this area and analyze the risk factors. Methods From January 2016 to December 2017， 500 children aged 5 weeks to enrolled in the physical examination were convenient selected as the subject of this study， including 210 cases of Houlong Hospital and 290 cases of MCH. All children were tested for serum Hp-IgG and questionnaires were made with parents of all subjects. Serum samples were positive for the case group， and negative results were for the control group. Results Of the 500 school-aged children in this study， 83 were positive for serum Hp-IgG， the positive rate was 16.6%， the remaining 417 were negative， and the negative rate was 83.4%. Questionnaire survey of school-age children-related lifestyles， and through univariate χ2 analysis， multivariate Logistic regression analysis found that the main risk factors affecting school-age children infected with Helicobacter pylori， including parents of Hp-IgG positive （OR= 2.384，CI： 1.365 to 1.881， P=0.01）， Aiwa fingers （OR=3.019， CI 2.014 to 4.362， P=0.01）， common tableware or dental appliances with parents （OR=3.375， CI： 2.833 to 4.018， P=0.000） and age （OR=3.788，CI：2.035 to 3.980， P=0.000）. Conclusion The prevalence of Helicobacter pylori in school-age children is relatively high. It is important to prevent or treat Helicobacter pylori infection actively， strengthen education， enhance children's health awareness， and develop good living habits to prevent Helicobacter pylori infection.

[Key words] School-age children; Helicobacter pylori; Risk factors

自从Marshall和Warren在1982年从胃粘膜中分离出幽门螺杆菌以后，人们开始逐渐意识到该细菌与慢性胃炎、胃溃疡以及胃部恶性肿瘤的发生紧密相关，属于人类极易感染的一種细菌[1-2]。目前一些研究显示，儿童时期比较容易感染幽门螺杆菌，且发病率与年龄呈现正相关[3]。且由于临床症状不明显极易被忽略治疗，故而使得这部分人群在成年后极易发生胃溃疡，甚至胃癌，早期诊断、早期治疗效果非常明显。……