董明慧

[摘要] 目的 探讨左卡尼汀对糖尿病合并心力衰竭老年患者的治疗效果。方法 选取该院2017年5月—2018年5月收治的糖尿病合并心力衰竭老年患者36例，随机分为两组，各18例，对照组给予常规治疗，观察组在对照组的基础上给予左卡尼汀。结果 观察组总有效率为94.4%，明显优于对照组77.8%，差异有统计学意义（P<0.05）；观察组CO、LVEF显著高于对照组，FPG、LVEDD显著低于对照组，差异有统计学意义（P<0.05）。结论 左卡尼汀治疗糖尿病合并心力衰竭老年患者效果显著，能有效改善患者心功能，控制血糖。

[关键词] 左卡尼汀；糖尿病；心力衰竭

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2018）08（b）-0073-02

Therapeutic Effect of L-carnitine on Elderly Patients with Diabetes Mellitus Complicated with Heart Failure

DONG Ming-hui

Changchun Central Hospital， Cadre Treatment Area， Changchun， Jilin Province， 130000 China

[Abstract] Objective To investigate the therapeutic effect of L-carnitine on elderly patients with diabetes mellitus complicated with heart failure. Methods Thirty-six elderly patients with diabetes mellitus complicated with heart failure admitted to the department from May 2017 to May 2018 were randomly divided into two groups， with 18 cases in each group， the control group was given routine treatment， and the observation group was given left carnitine on the basis of the control group. Results The total effective rate of the observation group was 94.4%， which was significantly better than that of the control group （77.8%），the differeent was statistically significant（P<0.05）. The CO and LVEF in the observation group were significantly higher than those in the control group， and the FPG and LVEDD were significantly lower than the control group，the differeent was statistically significant（P<0.05）. Conclusion L-carnitine is effective in the treatment of elderly patients with diabetes mellitus complicated with heart failure， which can effectively improve the heart function and control blood glucose.

[Key words] L-carnitine； Diabetes； Heart failure

近年來，我国老龄化人群不断增多，糖尿病在老年人中的发病率也呈逐年上升趋势，同时许多老年患者还伴有高血压、冠心病等疾病，易引起心肌收缩力减弱，导致心力衰竭的发生[1]。心力衰竭是一种心肌细胞能量代谢紊乱现象，也是心脏疾病的最后阶段，研究表明[2]，糖尿病患者发生心衰的机率是非糖尿病患者的2～3倍。改善心肌能量代谢，减少心肌损伤是改善患者心功能和预后的关键。该科对2017年5月—2018年5月收治的18例糖尿病合并心力衰竭老年患者采用左卡尼汀治疗并观察，现报道如下。

1 资料与方法

1.1 一般资料

选取该院收治的糖尿病合并心力衰竭老年患者36例为观察对象，随机分为两组，各18例，观察组男11例，女7例，年龄60～84岁，平均年龄（70.3±2.5）岁，糖尿病病程4～14年，平均病程（8.7±1.2）年，心衰病程3～8年，平均病程（4.5±1.0）年，NYHA分级：Ⅲ级12例，Ⅳ级6例。对照组男13例，女5例，年龄60～82岁，平均年龄（69.7±2.1）岁，糖尿病病程4～14年，平均病程（8.0±0.9）年，心衰病程3～7年，平均病程（4.1±0.8）年，NYHA分级：Ⅲ级14例，Ⅳ级4例。排除合并严重肝肾、恶性肿瘤、脑血管疾病者。患者均知情同意并经伦理委员会批准。……