石昭学

[摘要] 目的 探索妊娠期糖尿病與妊娠期高血压疾病与孕妇体重变化情况和妊娠结局相关性研究。方法 收集2012年5月—2018年5月在该院做妊娠期检查和分娩的孕产妇1 560例。分为正常妊娠组（1 048例）、HDCP组（250例）、GDM组（216例）、HDCP合并GDM组（46例），比较各组孕妇12、30周的体重变化和妊娠结局。结果 4组孕妇12、30周的体重比较差异有统计学意义。HDCP合并GDM组、HDCP组、GDM组的体重分别都显著高于正常妊娠组（P<0.05）。HDCP合并GDM组均显著高于HDCP组、GDM组（P<0.05）；4组孕妇的胎膜早破、早产、产后出血、新生儿黄疸发生率比较均差异有统计学意义（P<0.05）。HDCP合并GDM组、HDCP组、GDM组的不良妊娠结局发生率分别都显著高于正常妊娠组（P<0.05）。HDCP合并GDM组均显著高于HDCP组、GDM组（P<0.05）。结论 孕早期体重增加、孕期体重过多增长的人群易发生GDM和HDCP。GDM组和HDCP组增加了孕产妇和婴儿的不良妊娠结局的风险，所以加强对高危人群合理干预，可以降低并发症的发生率，改善孕产妇健康状况。

[关键词] 妊娠期糖尿病；妊娠期高血压；妊娠结局；相关性

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2018）08（b）-0006-03

Correlation between Gestational Diabetes Mellitus and Hypertensive Disorder Complicating Pregnancy and Changes in Body Weight and Pregnancy Outcome in Pregnant Women

SHI Zhao-xue

Department of Obstetrics and Gynecology， Rugao Port People's Hospital， Rugao， Jiangsu Province， 226500 China

[Abstract] Objective To explore the relationship between gestational diabetes mellitus and hypertensive disorder complicating pregnancy and the changes of body weight and pregnancy outcome in pregnant women. Methods A total of 1 560 pregnant women who underwent pregnancy examination and delivery from May 2012 to May 2018 were collected. The patients were divided into normal pregnancy group（1 048 cases）， HDCP group （250 cases）， GDM group （216 cases）， HDCP combined with GDM group （46 cases）， and the weight changes and pregnancy outcomes of pregnant women at 12 weeks and 30 weeks of pregnancy were compared. Results There were significant differences in body weight between the 4 groups of pregnant women of 12 weeks and the 30 weeks of pregnancy. The body weights of HDCP combined with GDM group， HDCP group and GDM group were significantly higher than those of normal pregnancy group（P<0.05）. The HDCP and GDM groups were significantly higher than the HDCP group and the GDM group（P<0.05）. The premature rupture of membranes， premature delivery， postpartum hemorrhage， and neonatal jaundice were significantly different among the 4 groups（P<0.05）. The incidence of adverse pregnancy outcomes in HDCP combined with GDM group， HDCP group and GDM group were significantly higher than those in normal pregnancy group（P<0.05）. HDCP combined with GDM group were significantly higher than HDCP group and GDM group（P<0.05）. Conclusion GDM and HDCP are prone to occur in people who gain weight during early pregnancy and gain weight during pregnancy. The GDM group and the HDCP group increase the risk of adverse pregnancy outcomes in pregnant women and infants， so strengthening rational intervention in high-risk groups can reduce the incidence of complications and improve maternal health.

[Key words] Gestational diabetes； Pregnancy-induced hypertension； Pregnancy outcome； Correlation

妊娠期糖尿病（GDM）和妊娠期高血压（HDCP）都会影响孕妇的身体状况和妊娠结局[1]。随着医疗技术的发展，目前对GDM和HDCP依旧缺乏有效的治疗手法，所以多以预防为主[2-3]。随着人民生活水平的提高，妇女孕期体重增长较为普遍，随之以来增加了GDM、HDCP的发病率，研究显示GDM和HDCP会增加妊娠结局的风险，并且孕产妇和婴儿患病率和死亡率也逐渐增加。妊娠糖尿病属于妊娠期的一種并发症，表现为孕前没有糖尿病，而孕期会出现血糖异常，与孕妇体内胰岛素不足有关，妊娠糖尿病不但会影响妊娠结局还会提高母婴糖尿病的概率。该文收集2012年5月—2018年5月在该院做妊娠期检查和分娩的孕产妇1 560例。分为正常妊娠组（1 048例）、HDCP组（250例）、GDM 组（216例）、HDCP合并GDM 组（46例），比较各组孕妇12、30周的体重变化和妊娠结局。探索妊娠期糖尿病与妊娠期高血压疾病与孕妇体重变化情况和妊娠结局相关性，为早期诊断和识别这些疾病的高发人群，以期及早指导干预孕产妇妊娠期。……