王艳

[摘要] 目的 探析對高热惊厥患儿进行血清及脑脊液NSE（神经元特异性烯醇化酶）测定的临床价值，旨在探讨高热惊厥发作后对患儿是否存在脑损伤情况。 方法 方便选取该院在2014年7月—2017年12月期间收治的88例高热惊厥患儿，将其分为复杂性高热惊厥患儿作为A组（n=39），单纯性高热惊厥患儿，作为B组（n=49），另选取同期40例住院患儿作为对照组，均给予血清、脑脊液NSE水平检测，比较3组NSE水平表达情况。结果 A组血清NSE水平（26.83±6.22）ng/mL显著高于B组、对照组的（21.62±5.67）ng/mL、（13.29±5.37）ng/mL，差异有统计学意义（t=4.28， 8.692，P<0.05）；B组显著高于对照组，比较差异有统计学意义（t=5.739，P<0.05）；A组、B组脑脊液NSE水平分别为（19.42±4.38）ng/mL、（17.37±5.22）ng/mL，显著高于对照组（11.46±4.12）ng/mL，差异有统计学意义（t=5.284，5.792，P<0.05）。 A组、B组脑脊液NSE水平比较差异无统计学意义（t=1.812，P>0.05）。结论 对高热惊厥患儿测定血清及脑脊液NSE水平，复杂性高热惊厥患儿的NSE水平升高更为明显，这对判断患儿是否存在脑损伤具有一定的临床价值，值得临床推广。

[关键词] 高热惊厥；血清；脑脊液；NSE；临床意义

[中图分类号] R720 [文献标识码] A [文章编号] 1674-0742（2018）08（b）-0188-03

Detection and Its Significance of Serum and Cerebrospinal Fluid NSE in Children with Hyperthermia Convulsions

WANG Yan

Department of Pediatrics， Hongquan Hospital， Yangzhou， Jiangsu Province， 225200 China

[Abstract] Objective To analyze the clinical value of serum and cerebrospinal fluid NSE （neuron specific enolase） in children with febrile convulsions in order to investigate whether there is brain injury in children after episodes of hyperthermia. Methods 88 children with febrile convulsions admitted to the hospital from July 2014 to December 2017 were divided into group A （n=39） and hypertensive seizures as group B （n=49）， another 40 consecutive hospitalized children were convenient selected as the control group. NSE levels in serum and cerebrospinal fluid were measured and the levels of NSE levels in the three groups were compared. Results Serum NSE levels in group A （26.83±6.22）ng/mL were significantly higher than those in group B and control group （21.62±5.67） ng/mL and （13.29±5.37）ng/mL， showing significant differences （t=4.28， 8.692， P<0.05）； group B was significantly higher than the control group， the difference was significant （t = 5.739， P<0.05）； group A ， B CSF NSE levels were（19.42 ± 4.38）ng/mL，（17.37±5.22）ng/mL was significantly higher than that in the control group （11.46±4.12）ng/mL， with significant difference（t=5.284， 5.792， P<0.05）. There was no significant difference in the level of NSE in CSF between group A and B（t=1.812， P>0.05）. Conclusion The serum and cerebrospinal fluid levels of NSE in children with febrile convulsions were detected. The level of NSE in children with complex febrile convulsions increased more significantly. This has certain clinical value in judging the existence of brain injury in children and is worthy of clinical promotion.

[Key words] Hyperthermia； Serum； Cerebrospinal fluid； NSE； Clinical significance

高热惊厥为临床十分常见的危急病症之一，在临床上，又将其分为单纯性高热惊厥和复杂性高热惊厥[1]。患儿发生高热惊厥后会出现暂时性的脑功能障碍，因此，可能会导致患儿出现不可逆的脑损伤，而严重、频繁的热性惊厥发生在临床上与癫痫持续状态相似，会引发惊厥性脑损伤，甚至发展为癫痫[2-3]。NSE（神经元特异性烯醇化酶）是临床用于评价脑损伤的特异性指标，也是较为敏感的客观量化指标，为进一步探讨对高热惊厥患儿进行血清及脑脊液NSE测定的临床价值，该文将2014年7月—2017年12月期间收治的88例高热惊厥患儿，作为研究对象，现报道如下。

1 资料与方法

1.1 一般资料

方便选取该院收治的88例高热惊厥患儿，经过伦理委员会批准，患者或家属知情同意。……