许芬芳　黄滨宁

[摘要] 目的 头孢唑啉钠与妥布霉素联合应用对细菌性角膜溃疡的临床疗效与应用价值。 方法 选取我院2014年9月～2016年10月期间收治的65例细菌性角膜溃疡患者，分为观察组与对照组。对照组所有患者均采用5%头孢唑啉钠眼药水与0.8%庆大霉素眼药水交替滴眼治疗；观察组所有患者均采用5%头孢唑啉钠眼药水与妥布霉素眼药水交替滴眼治疗。比较两组疗效及各项临床数据差异。 结果 两组疗效对比，观察组显著高于对照组（P<0.05）；治疗后，观察组患者治疗时间与术后恢复所需时间明显优于对照组，组间差异显著（P<0.05）。 结论 头孢唑啉钠联合妥布霉素对细菌性角膜溃疡患者治疗效果显著，通过两组药物相互促进的药理作用可缩短治疗时间，且用药较为安全，有临床推广应用价值。

[关键词] 头孢唑啉钠；妥布霉素；细菌性角膜溃疡；结膜充血；药理作用

[中图分类号] R772.21 [文献标识码] B [文章编号] 1673-9701（2018）20-0116-03

Observation on the therapeutic effect of cefazolin sodium combined with tobramycin on bacterial corneal ulcer

XU Fenfang HUANG Binning

Clinical Laboratory，Xiamen Eye Center of Xiamen University，Xiamen 361001，China

[Abstract] Objective To explore the clinical efficacy and application value of cefazolin sodium combined with tobramycin on bacterial corneal ulcer. Methods 65 patients with bacterial corneal ulcers who were admitted to our hospital from September 2014 to October 2016 were selected and divided into observation group and control group. All patients in the control group were given 5% cefazolin sodium eye drop and 0.8% gentamicin eye drop alternately. All patients in the observation group were given 5% cefazolin sodium eye drop and tobramycin eye drop alternately. The efficacy and the differences in various clinical data were compared between the two groups. Results The efficacy in the observation group was significantly higher than that in the control group（P<0.05）； the treatment time and the time required for postoperative recovery in the observation group were significantly better than those in the control group after treatment， with significant differences between groups（P<0.05）. Conclusion Cefazolin sodium combined with tobramycin has a significant clinical efficacy in the patients with bacterial corneal ulcers. Through the pharmacological action of mutual promotion of the two drugs， the treatment time can be shortened， and the use of drugs is safer， which has a clinical value of application and promotion.

[Key words] Cefazolin sodium； Tobramycin； Bacterial corneal ulcer； Conjunctival congestion； Pharmacological action

细菌性角膜溃疡是临床治疗中较为常见的一类疾病，其发病原因多为角膜外伤后感染或剔除角膜异物感染[1]。除此之外，一切局部或是全身疾病，如干眼症、配戴角膜接触镜、糖尿病、免疫缺陷、酗酒可能降低机体的免疫功能，从而使细菌感染角膜的机会增加[2]。细菌性角膜溃疡对人体的危害较大，且病情进展迅速，患者一旦患病若不及时进行有效的治疗，通常会出现各类并发症，并且会对视力造成严重的损害[3]。临床上针对细菌性角膜溃疡患者主要采用药物治疗，但具有一定疗效的药物较多。因此，對药物选择的合理性、科学性成为我院主要研究课题。本次研究选取我院2014年9月～2016年10月期间收治的65例细菌性角膜溃疡患者，就头孢唑啉钠与妥布霉素联合应用对细菌性角膜溃疡的临床疗效与应用价值进行具体分析。……