翁金燕　翁丽燕　翁巧优

[摘要] 目的 觀察高聚金葡素联合TP方案治疗中晚期非小细胞肺癌的临床疗效。 方法 64例患者随机分为对照组（n=32）和治疗组（n=32），对照组给予TP治疗方案，治疗组给予TP治疗方案的基础上加用高聚金葡素。比较治疗前后的近期疗效、不良反应和生活质量的改善情况。 结果 治疗组近期疗效的有效率（78.13%）优于对照组（53.13%），差异有统计学意义（P<0.05）。两组患者的生活质量比较，其中治疗组的KPS评价方面，改善率（78.13%）显著优于对照组（56.25%）（P<0.05）；体质量的改善方面，治疗组（81.25%）显著优于对照组（59.38%），差异有统计学意义（P<0.05）。对照组患者血清的TNF-α和IL-6水平显著下降，治疗组患者血清TNF-α和IL-6水平显著升高。两组不良反应率差异无统计学意义（P>0.05）。 结论 高聚金葡素联合TP方案在近期疗效的有效率，患者的生活质量以及不良反应的发生率与TP方案比较有显著的改善。

[关键词] 高聚金葡素；TP方案；非小细胞肺癌；TNF-α；IL-6

[中图分类号] R734.2 [文献标识码] B [文章编号] 1673-9701（2018）20-0101-04

Therapeutic effect of highly agglutinative staphylococcin combined with TP regimen in the treatment of advanced non - small cell lung cancer

WENG Jinyan1 WENG Liyan1 WENG Qiaoyou2

1.Department of Pharmacy，Lishui City Central Hospital in Zhejiang Province，Lishui 323000，China；2.Department of Interventional Radiology，Lishui City Central Hospitalin in Zhejiang Province，Lishui 323000，China

[Abstract] Objective To observe the clinical efficacy of highly agglutinative staphylococcin combined with TP regimen in the treatment of advanced non-small cell lung cancer. Methods 64 patients were randomly divided into control group（n=32） and treatment group（n=32）. The control group received TP treatment and the treatment group was treated with highly agglutinative staphylococcin based on the TP treatment. The short-term curative effect， adverse reaction and quality of life before and after treatment were compared. Results The effective rate（78.13%） of the short-term curative effect in the treatment group was better than that in the control group（53.13%）， and the difference was statistically significant（P<0.05）. The quality of life of the two groups was compared. In the aspect of KPS evaluation between two groups， the improvement rate（78.13%） in the treatment group was significantly better than that of the control group （56.25%）（P<0.05）. The improvement rate of overall quality of life in the treatment group（81.25%） was significantly higher than that of the control group（59.38%）， with statistically significant difference（P<0.05）. The levels of TNF-α and IL-6 in the serum of patients in the control group decreased significantly， and the levels of serum TNF-α and IL-6 in the patients in the treatment group were significantly increased. There was no significant difference in adverse reaction rate between the two groups（P>0.05）. Conclusion The improvement of effectiveness of short-term curative effect， patients quality of life and the incidence of adverse reactions of the combination therapy of highly agglutinative staphylococcin and TP is more significant than that of the TP regimen.

[Key words] Highly agglutinative staphylococcin；TP regimen；Non-small cell lung cancer； TNF-α；IL-6

肺癌是发病率和死亡率增长最快，对人群健康和生命威胁最大的恶性肿瘤之一，已成为我国城市人口恶性肿瘤死亡原因的首位[1-2]。非小细胞型肺癌（non-small cell lung cancer，NSCLC）包括鳞状细胞癌（鳞癌）、腺癌、大细胞癌，与小细胞癌相比其癌细胞生长分裂较慢，扩散转移相对较晚[3]。非小细胞肺癌约占所有肺癌的80%～85%，约75%的患者发现时已处于中晚期，5年生存率很低。本研究以高聚金葡素联合TP方案治疗非小细胞肺癌，取得良好效果。

1 资料与方法

1.1 一般资料

选取我院于2015年10月～2017年5月收治的非小细胞肺癌中晚期患者共64例。入选标准：（1）经病理学或细胞学确诊，有可测量病灶；（2）预计生存期在3个月以上；（3）年龄为20～70岁；（4）卡式评分[4-5]（Karno fsky performance status，KPS）≥60分；（5）血常规、肝肾功能和心电图检查结果基本正常；（6）未经其他化，放疗或结束2个月以上。排除标准：（1）正在进行放疗或放疗结束未超过2个月者；……