王浩人

[摘要] 目的 研究老年早期糖尿病肾脏疾病采取α硫辛酸联合脂微球前列地尔治疗的临床效果。 方法 2017年1—12月间将老年早期糖尿病肾脏疾病病患72例，按抽签法分为参照组各36例给予脂微球前列地尔治疗，研究组36例在其基础上联合α硫辛酸治疗。比较两组治疗前后尿微量清蛋白（mAIb）、尿视黄醇结合蛋白（U‐RBP）、尿N‐乙酰β-D 氨基葡萄糖苷酶（NAG）等生化指标检测结果，以及治疗效果。 结果 两组治疗前mAIb、U‐RBP、NAG等生化指标检测比较差异无统计学意义（P>0.05），经治疗后研究组mAIb、U‐RBP、NAG等生化指标均显著低于参照组；治疗总有效率94.44%显著高于参照组的75.00%，差异有统计学意义（P<0.05）。 结论 对老年早期糖尿病肾脏疾病病患联用α硫辛酸和脂微球前列地尔治疗，有利于改善病患肾小管和肾小球功能，进而提高临床治疗效果。

[关键词] 早期糖尿病；肾脏疾病；α硫辛酸；脂微球前列地尔

[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062（2018）06（b）-0193-02

Clinical Observation of α-lipoic Acid Combined with Lipid Microspheres Alprostadil in Early-stage Diabetic Kidney Disease

WANG Hao-ren

Department of Endocrinology， Luozhuang Central Hospital， Linyi， Shandong Province， 276017 China

[Abstract] Objective To study the clinical effect of α-lipoic acid combined with liposphere alprostadil in the treatment of early diabetic nephropathy. Methods From January to December 2017 seventy-two elderly patients with early-stage diabetic kidney disease were divided into three groups according to the sampling method. 36 patients were treated with liposphere alprostadil， and 36 patients in the study group were treated with alpha lipoic acid. The results of biochemical indicators such as urinary microalbumin （mAIb）， ？？urinary retinol binding protein （U-RBP）， and urine N-acetyl β-D glucosaminidase （NAG） were compared before and after treatment. Results There were no significant differences in the biochemical parameters of mAIb， U‐RBP and NAG before treatment （P>0.05）. After treatment， the biochemical parameters such as mAIb， U‐RBP and NAG were significantly lower than the reference group. The total effective rate of treatment was 94.44% significantly higher than that of the reference group （75.00%）， and the difference was statistically significant （P<0.05）. Conclusion The combination of alpha lipoic acid and lipid microspheres of alprostadil in patients with early diabetic nephropathy is beneficial to improve renal tubular and glomerular function and improve clinical treatment.

[Key words] Early diabetes； Kidney disease； Alpha lipoic acid； Lipid microspheres alprostadil

糖代謝失常是引发糖尿病肾脏疾病的主要原因，其是糖尿病比较多发的微血管并发症之一[1]。尽管严格管控血压、血糖可使部分糖尿病微血管病变的发生和发展延缓，但是其对糖尿病肾脏疾病发展作用不大，如果不采取及时有效的治疗措施，将会发展为终末期肾脏疾病，此时病情通常无法逆转，往往需通过透析来维持生命[2]。因此，早诊断，早治疗对延缓甚至逆转糖尿病肾脏疾病具有重要意义。为此，该文特对老年早期糖尿病肾脏疾病采取α硫辛酸联合脂微球前列地尔治疗的临床效果开展了研究分析，现分析2017年1月—2017年12月间该院收治的72例糖尿病肾病患者的临床资料，详情如下。

1 资料与方法

1.1 一般资料

将该院收治的老年早期糖尿病肾脏疾病病患72例作为研究对象，按抽签法分为参照组和研究组各36例，参照组男性20例，女性16例；年……