周振环 李君 范华 吕春颖

[摘要] 目的 观察乌梅消食颗粒联合硫酸亚铁在脾胃虚弱型缺铁性贫血治疗中作用。 方法 选择2015年5月～2017年5月廊坊市中医医院诊断为脾胃虚弱型缺铁性贫血的患者92例，按照随机数字表法分为治疗组和对照组，每组各46例，对照组采用硫酸亚铁片口服，治疗组在服用硫酸亚铁前20 min开水冲服乌梅消食颗粒，30 d为1个疗程，观察两组疗效、血常规、铁代谢及副作用情况。 结果 治疗1个疗程后，两组患者疗效差异无统计学意义（P > 0.05）， 但治疗组患者的血常规及铁代谢指标较对照组明显改善，且治疗组不良反应明显减少，差异有统计学意义（P < 0.05）。 结论 乌梅消食颗粒联合硫酸亚铁治疗脾胃虚弱型缺铁性贫血，可明显改善患者贫血指标，增加机体铁储备，减少铁剂对消化道的刺激作用，效果优于单用铁剂。

[关键词] 乌梅消食颗粒；硫酸亚铁；脾胃虚弱；缺铁性贫血

[中图分类号] R556.3 [文献标识码] A [文章编号] 1673-7210（2018）06（b）-0119-04

[Abstract] Objective To observe the effect of Wumei Xiaoshi Granule combined with ferrous sulfate in the treatment of iron deficiency anemia （IDA） of spleen-stomach deficiency. Methods From May 2015 to May 2017， in Langfang TCM Hospital， 92 patients with IDA of spleen-stomach deficiency were divided into treatment group （n = 46） and control group （n = 46） according to the random number table. The control group was treated with ferrous sulfate tablets， the treatment group was treated with Wumei Xiaoshi Granule 20 min before ferrous sulfate tablets， 30 d for a course of treatment. The efficacy， blood routine examination， iron metabolism and side effects were observed. Results There was no significant difference in the curative effect between the two groups （P > 0.05）. However， the blood routine test and iron metabolism in the treatment group were significantly improved compared with the control group， the differences were statistically significant （P < 0.05）. Conclusion Wumei Xiaoshi Granule combined with ferrous sulfate in the treatment of IDA of spleen-stomach deficiency can significantly improve the anemia symptoms， increase the body iron reserve and reduce the stimulation effect， and the effect is better than ferrous sulfate only.

[Key words] Wumei Xiaoshi Granule； Ferrous sulfate； Spleen-stomach deficiency； Iron deficiency anemia

缺鐵性贫血（Iron deficiency anemia，IDA）是最常见的营养缺乏性疾病，是威胁发展中国家女性和儿童的第一大贫血原因。IDA是指体内贮存的铁缺乏导致血红素合成减少所引起的贫血，主要由于铁摄入不足、吸收不足、需求量增加或损失过多等原因导致，是临床常见的一种小细胞低色素型贫血[1]。该病可引起抵抗力下降、工作、学习能力下降、生长发育迟滞等一系列不良后果，是全球普遍卫生问题，在发展中国家情况尤为严重[2]。补充铁剂及查找并去除缺铁的原因是治疗IDA的主要手段，目前补充铁剂的主要办法为口服铁剂及注射用铁剂，两者均有一定副作用，尤其是注射用铁剂有13%～26%患者可有明显不良反应[3]，临床应严格掌握使用指征。经过……