翟纪功 朱园园 庞国明 王志强

【摘 要】 目的：观察黄芪桂枝五物汤联合西药治疗糖尿病周围神经病变的临床疗效。方法：选取糖尿病周围神经病变56例为研究对象，随机分为对照组和观察组各28例。对照组进行常规治疗，观察组在对照组的基础上加用黄芪桂枝五物汤治疗，比较临床疗效。结果：观察组总有效率为96.43%，优于对照组的71.43%，差异具有统计学意义（P<0.05）。治疗后观察组的微循环与神经功能指标均优于对照组，差异具有统计学意义（P<0.05）。结论：黄芪桂枝五物汤联合西药治疗糖尿病周围神经病变临床效果较好，对微循环与神经功能的改善作用较好，值得临床推广。

【关键词】 糖尿病周围神经病变；微循环；神经功能；黄芪桂枝五物汤

【中图分类号】R587.2 【文献标志码】 A【文章编号】1007-8517（2018）13-0121-03

Abstract：Objective To observe the clinical effect of Huangqi Guizhi Wuwu decoction combined with western medicine in patients with diabetic peripheral neuropathy.Methods 56 patients with diabetic peripheral neuropathy were selected as the study object，and they were randomly divided into control group and observation group（conventional treatment and Huangqi Guizhi Wuwu decoction group） with 28 cases in each group.The control group were treated with conventional treatment，the observation group were treated with Huangqi Guizhi Wuwu decoction on the treatment of control group.Then the clinical effect were compared.Results The total effective rate of observation group was 96.43%，and it was higher than 71.43% of control group，there was significant difference（P<0.05），the mircrocirculation and nerve function indexes of observation group after the treatment were all better than those of control group，there were all significant differences（P<0.05）.Conclusion The clinical effect of Huangqi Guizhi Wuwu decoction combined with western medicine in patients with diabetic peripheral neuropathy is better，and its improvement for the mircrocirculation and nerve function is better，so it is worthy of clinical application.

Keywords：Diabetic Peripheral Neuropathy；Mircrocirculation ；Nerve Function；Huangqi Guizhi Wuwu Decoction

糖尿病周圍神经病变是糖尿病的常见严重并发症之一，患者的微循环状态较差，局部血供不足，神经功能受损，因此对患者治疗的过程中，微循环与神经功能的改善是治疗的重点[1]。另外，微循环对神经功能也有较大的影响，因此其改善的需求进一步提升。近年来以中药治疗糖尿病并发症患者的研究增多[2]，效果多较好。本次我院采用黄芪桂枝五物汤联合西药治疗糖尿病周围神经病变取得一定疗效，现报道如下。

1 资料与方法

1.1 一般资料 选取2016年1月至2017年12月期间我院收治的糖尿病周围神经病变56例为研究对象，随机分为对照组和观察组各28例。对照组男16例，女12例，年龄为32～74岁，平均（51.6±10.3）岁，病程为2.9～28.9年，平均为（7.8±1.3）年；其中轻度病变者20例，中重度病变者8例。观察组男15例，女13例，年龄为31～75岁，平均（52.0±9.9）岁，病程为2.9～30.5年，平均为（7.9±1.4）年；其中轻度病变者19例，中重度病变者9例。两组性别、年龄、病程等一般资料比较差异无统计学意义（P>0.05），具有可比性。……