肖静

【摘 要】目的：探讨真菌类微生态制剂-布拉氏酵母菌预防抗生素相关性腹泻的疗效。方法：将2017年11月至2018年2月期间，在妇幼保健院小儿内科一病区病房，急性支气管肺炎住院患儿92例，随机分为两组，干预组46例，对照组46例。两组均给予头孢他啶抗感染及对症支持治疗，其中干预组在上述治疗基础上同时加服布拉氏酵母菌散剂。分别记录干预组与对照组的病人，继发性腹泻的每日大便次数、腹泻发生率、腹泻持续时间，进行统计分析。结果：干预组继发腹泻3例，发病率为6.52%，对照组腹泻12例，发病率为26.08%。干预组在继发腹泻发生率、腹泻持续时间明显优于对照组。结论：布拉氏酵母菌预防抗生素相关性腹泻具有积极的预防作用。

【关键词】布拉氏酵母菌；抗生素相关性腹泻；疗效观察

中图分类号： R725.7 文献标识码： A 文章编号：2095-2457（2018）08-0192-002

Observing the Curative Effect of Brasilia on Preventing Antibiotic-associated Diarrhea

XIAO Jing

（Nanning Health School， Nanning， Guangxi 530000， China）

【Abstract】Objective： To investigate the efficacy of fungal probiotics-Brassicanae in the prevention of antibiotic-associated diarrhea. METHODS： From November 2017 to February 2018， 92 cases of hospitalized acute bronchopneumonia in a pediatric pediatric department ward were randomly divided into two groups， 46 cases in the intervention group and 46 cases in the control group. Both groups were given ceftazidime for anti-infection and symptomatic and supportive treatment. The intervention group was additionally given a powder of Brassella cerevisiae on the basis of the above treatment. The frequency of daily stool， diarrhea， and duration of diarrhea in patients with interventional and control groups were recorded. Statistical analysis was performed. Results： In the intervention group， there were 3 cases of secondary diarrhea， the incidence rate was 6.52%， and the control group had 12 cases of diarrhea. The incidence rate was 26.08%. The incidence of secondary diarrhea and duration of diarrhea were significantly better in the intervention group than in the control group. Conclusion： Bradschia has a prophylactic effect in the prevention of antibiotic-associated diarrhea.

【Key words】Blaces yeast； Antibiotic-associated diarrhea； Curative effect observation

小儿支气管肺炎多为社区获得性肺炎（CAP），是儿童期尤其是婴幼儿常见感染性疾病，是儿童住院的最常见原因，也是5岁以下儿童死亡的首位病因[1]。静脉途径应用抗生素是治疗支气管肺炎的重要措施，而大多抗生素在使用过程中可伴随引起抗生素相关性腹泻（AAD），尤其是广谱抗生素克林霉素、氨基青霉素、头孢菌素等。本文主要研究布拉氏酵母菌在靜脉途径下应用抗生素治疗小儿急性支气管肺炎，有效降低其抗生素相关性腹泻的发病率，现总结报告如下。

1 材料与方法

1.1 研究对象

选取对象为2017年11月到2018年2月期间，在妇幼保健院小儿内科一……