周志鹏 叶烈夫 洪怀山 刘志华 杨泽松

[摘要] 目的 探討地奥司明在预防不同手术方式下行包皮环切术后水肿的效果。 方法 回顾性分析福建省立金山医院泌尿外科2015年6月—2017年8月期间160例行包皮环切术的患者，其中109例行传统包皮环切术，53例予一次性包皮环切缝合器行包皮环切术，采用随机数字法将109例采用传统包皮环切术的患者分为A1（对照组54例）、A2（实验组55例）组，53例予一次性包皮环切缝合器行包皮环切术的患者分为B1（对照组27例）、B2（实验组26例），A2、B2组术后当天即给予抗感染、止痛、抗勃起等药物及口服地奥司明0.5 g，2次/d，共7 d，A1、B1组仅给予抗感染、止痛、抗勃起等药物。分别于术后3、7、14 d观察包皮水肿情况。 结果 A1对照组术后3、7、14 d出现水肿例数35、13、2例，A2实验组术后3、7、14 d出现水肿例数14、4、1例。B1对照组术后3、7、14 d出现水肿例数10、8、4例。B2实验组术后3、7、14 d出现水肿例数3、2、1例。在109例采用传统包皮环切术的患者术后水肿观察中发现，A1、A2组术后3、7 d的水肿发生率差异有统计学意义；14 d的水肿发生率差异无统计学意义。53例予一次性包皮环切缝合器行包皮环切术的患者术后水肿观察中发现，B1、B2组术后3 d、7 d的水肿发生率差异有统计学意义；14 d的水肿发生率差异无统计学意义。 结论 早期应用地奥司明对于预防及缓解不同手术方式下行包皮环切术后水肿有显著疗效。

[关键词] 地奥司明；包皮环切术；水肿

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）02（a）-0107-04

Clinical Analysis of Diosmin in Preventing Edema after Circumcision under Different Surgical Methods

ZHOU Zhi-peng， YE Lie-fu， HONG Huai-shan， LIU Zhi-hua， YANG Ze-song

Department of Urology， Jinshan Hospital， Fuzhou， Fujian Province， 350028 China

[Abstract] Objective This paper tries to study the oseltamivir in the prevention of different surgical approach circumcision edema effect. Methods Retrospective analysis of 160 cases of circumcision from June 2015 to August 2017 in the hospital， 109 cases of traditional circumcision， 53 cases of primary circumcision. A total of 109 patients with conventional circumcision were divided into A1 group （control group， 54 cases）， A2 group （55 cases in experimental group）， 53 patients with primary circumcision， the patients were divided into B1 group （control group， 27 cases） and B2 group （26 cases in the experimental group）. The patients in the A2 and B2 groups were treated with anti-infective， analgesic anti-erection and diosmin （0.5 g twice a day）， the total course of treatment for 7 days， A1， B1 group only to give anti-infection， analgesicandanti-erection. The edema of the foreskin was observed at 3 d， 7 d and 14 d after operation. Results There were 35， 13， 2 cases of edema in the A1 control group at 3 d， 7 d and 14 d after operation， and 14， 4， 1 cases were found in the A2 experimental group at 3 d， 7 d and 14 d after operation. B1 control group at 3 d， 7 d， 14 d after the number of cases of edema 10， 8， 4 cases. In the experimental group， the number of edema cases was 3， 2 and 1 after 3 d， 7 d and 14 days after operation. In the 109 patients with conventional circumcision， the incidence of edema was significantly different in the A1 and A2 groups at 3 d and 7 days after operation（P<0.05）. There was no significant difference in the incidence of edema in 14 days（P>0.05）. There was a significant difference in the incidence of edema in the B1 and B2 group at 3 d and 7 days after operation in the edema of the patients who had circumcision at the circumcision（P<0.05）. The incidence of edema was not significantly different at 14 days（P>0.05）. Conclusion Early application of osmium has a significant effect on the prevention and alleviation of edema after circumcision with different surgical methods.

[Key words] Diosmin； Circumcision； Edema

包皮过长是泌尿外科常见病，以门诊行包皮环切术为主要处理方式。手术虽较为简单，但出血、水肿最为常见，其中以水肿为甚。……