张平　张亚平　苏红亮　祝兰英

【摘要】 目的：观察盐酸米诺环素软膏在慢性牙周炎患者牙周状态及炎性应激改善中的作用。方法：选取2016年8月-2017年6月本院收治的慢性牙周炎患者210例，按照随机数字表法分为对照组和观察组，各105例。对照组进行常规牙周炎治疗，观察组在对照组基础上加用盐酸米诺环素软膏治疗，比较两组治疗前和治疗后1、2、4周的菌斑指数、牙龈指数、探诊深度、龈沟液和血清中的炎性细胞因子水平。结果：治疗前，两组菌斑指数、牙龈指数、探诊深度、龈沟液和血清炎性细胞因子水平比较，差异均无统计学意义（P>0.05）；治疗后1、2、4周，观察组菌斑指数、牙龈指数、探诊深度、龈沟液和血清炎性细胞因子水平均低于对照组，比较差异均有统计学意义（P<0.05）。结论：盐酸米诺环素软膏在慢性牙周炎患者牙周状态及炎性应激改善中的作用较好，临床应用价值较高，值得推广。

【关键词】 盐酸米诺环素软膏； 慢性牙周炎； 牙周状态； 炎性应激

Observation on the Effect of Minocycline Hydrochloride Ointment in the Improvement of Periodontal State and Inflammatory Stress of Patients with Chronic Periodontitis/ZHANG Ping，ZHANG Yaping，SU Hongliang，et al.//Medical Innovation of China，2017，14（35）：134-137

【Abstract】 Objective：To observe the effect of Minocycline Hydrochloride Ointment in the improvement of periodontal state and inflammatory stress of patients with chronic periodontitis.Method：A total of 210 patients with chronic periodontitis in our hospital from August 2016 to June 2017 were selected，according to the random number table，they were divided into control group and observation group，105 cases in each group.The control group were treated with conventional treatment of periodontitis，and observation group were treated with Minocycline Hydrochloride Ointment on the basis of the control group.The plaque index，gingival index，probing depth，gingival crevicular fluid and serum levels of inflammatory cytokines were compared between two groups before and after treatment 1，2，4 weeks.Result：Before treatment，the plaque index，gingival index，probing depth，gingival crevicular fluid and serum levels of inflammatory cytokines between two groups were compared，the differences were not statistically significant（P>0.05）.After treatment 1，2，4 weeks，the plaque index，gingival index，probing depth，gingival crevicular fluid and serum levels of inflammatory cytokines in observation group were better than those of control group，the differences were statistically significant（P<0.05）.Conclusion：The effect of Minocycline Hydrochloride Ointment in the improvement of periodontal state and inflammatory stress of patients with chronic periodontitis is better，has a high clinical value and is worth popularizing.

【Key words】 Minocycline Hydrochloride Ointment； Chronic periodontitis； Periodontal state； Inflammatory stress

First-authors address：Traditional Chinese Medicine Hospital of Jining City，Jining 272000，China

doi：10.3969/j.issn.1674-4985.2017.35.037

慢性牙周炎是口腔科的常見病，此类患者的牙周状态较差，呈现菌斑指数、牙龈指数及探诊深度的异常，同时患者的口腔局部炎性状态也极为突出[1-2]，因此在对慢性牙周炎患者进行治疗的过程中，牙周状态及龈沟液炎性指标的改善均是重要的方面[3-4]。本文就盐酸米诺环素软膏在慢性牙周炎患者牙周状态及炎性应激改善中的作用进行观察研究，现报道如下。endprint

1 资料与方法

1.1 一般资料 选取2016年8月-2017年6月本院收治的慢性牙周炎患者210例。纳入标准：20岁≤年龄≤60岁者。排除标准：合并其他慢性基础疾病者；合并其他口腔疾病者；精神疾病及其他不能配合治疗检查情况者；1周……