孙芳

[摘要] 目的 探究血清淀粉樣蛋白A联合C反应蛋白检测在手足口病患儿中的应用价值。方法 方便选取87例手足口病患儿，实施血清淀粉样蛋白A联合C反应蛋白检测，并归为观察组，针对另外100名健康体检儿童实施相同检查，并归为对照组；患者选取时间为2015年1月—2017年1月；观察两组检查结果并进行比较。 结果 针对手足口病患儿的诊断效能进行分析发现，血清淀粉样蛋白A的诊断特异度和阳性预测值均较高，其中血清淀粉样蛋白A的灵敏度为0.85，C反应蛋白的灵敏度为0.64，血清淀粉样蛋白A/C反应蛋白的灵敏度为0.72；比较两组C反应蛋白水平、血清淀粉样蛋白A水平和血清淀粉样蛋白A/C反应蛋白（SAA/CRP）比值，可见观察组患者的相关指标均高于对照组健康者，其中对照组C反应蛋白水平为（2.67±2.05）mg/L，观察组C反应蛋白水平为（12.29±10.25）mg/L，比较差异有统计学意义（P<0.05）。 结论 血清淀粉样蛋白A联合C反应蛋白检测在手足口病患儿中的诊断价值分析发现，其联合检测能够鉴别患者的疾病情况，对于临床合理用药有很大帮助，因此值得在临床中选择使用。

[关键词] 血清淀粉样蛋白A；C反应蛋白；检测；手足口病；诊断价值

[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742（2017）10（c）-0193-03

Diagnostic Value of Serum Amyloid A and C Reactive Protein in Children with Hand， Foot and Mouth Disease

SUN Fang

Department of Laboratory， Zaozhuang Hospital of TCM， Zaozhuang， Shandong Province， 277000 China

[Abstract] Objective This paper tries to explore the application value of detection of serum amyloid A and C reactive protein in children with HFMD. Methods 87 cases of children with HFMD detected serum amyloid A and C reactive protein were convenient selected and classified as the observation group， the other 100 cases of healthy children implemented the same inspection were classified as the control group. Patients were selected from January 2015 to January 2017 and the detection results of the two groups were observed and compared. Results According to the diagnostic performance analysis in patients with hand foot mouth disease， diagnostic specificity and positive predictive value of serum amyloid A were higher， the serum amyloid sensitivity of A was 0.85， the sensitivity of C reactive protein was 0.64， the sensitivity of serum amyloid A/C reactive protein 0.72； C reactive protein， serum amyloid A and serum amyloid A/C reactive protein（SAA/CRP） ratio， visible observation index patients were higher than those of the control group of healthy subjects， the level of the control group of C reactive protein was（2.67±2.05） mg/L， the level of C reactive protein in the observation group was （12.29±10.25）mg/L， with significant difference（P<0.05）. Conclusion The value of detection of amyloid A and C reactive protein in diagnosis of HFMD in the analysis found that the combined detection can identify patients with the disease， which is of great help for clinical rational use of drugs， so it is worthy of application in clinical practice.

[Key words] Serum amyloid A； C reactive protein； Detection； Hand foot and mouth disease； Diagnostic valueendprint

手足口病是临床中常见的传染性疾病，由肠道病毒引起，引发手足口病的肠道病毒有20多种（型），其中以柯萨奇病毒A16型（Cox A16）和肠道病毒71型（EV 71）最为常见。病情发生对儿童的健康和发育会产生影响，严重者甚至威胁患者生命。该次着重针对于2015年1月—2017年1月收治的100名健康儿童（对照组）和87例手足口病患者（观察组）实施血清淀粉样蛋白A联合C反应蛋白检测和分析，目的在于总结经验，现报道如下。

1 资料与方法

1.1 一般资料

方便选取100名健康儿童（对照组）和87例手足口病患者（观察组）实施血清淀粉样蛋白A联合C反应蛋白检测。……