游勇+李俊勇+伍爱金+伍援进+刘石姬

[摘要]目的 探究麻风溃疡患者免疫功能情况。方法 选择2016年1月～2017年5月在佛山市南海区红卫医院和佛山市南海区疾病预防控制中心门诊就诊的60例麻风溃疡患者为观察组，60例无溃疡的麻风患者为对照组，以及院和健康体检的健康者60例为健康组。分别检测三组受检者外周血淋巴细胞亚群（CD3+、CD3+CD4+、CD3+CD8+、CD16+CD56+、CD19+、CD4+/CD8+）和血清免疫球蛋白（Ig）水平。结果 健康组CD3+、CD3+CD4+、CD3+CD8+、CD16+CD56+、CD19+、CD4+/CD8+水平与对照组比较，差异无统计学意义（P>0.05）；观察组CD3+、CD3+CD4+、CD3+CD8+、CD16+CD56+、CD4+/CD8+水平显著低于对照组，CD19+水平高于对照组，差异有统计学意义（P<0.05）；健康组IgG、IgA、IgM水平与对照组比较，差异无统计学意义（P>0.05）；与对照组比较，观察组IgG、IgA、IgM水平显著升高，差异有统计学意义（P<0.05）。结论 麻风溃疡患者伴有体液免疫反应过度现象，细胞免疫功能下降与麻风溃疡的发生、发展有密切的联系。

[关键词]麻风溃疡；免疫功能；淋巴细胞亚群

[中图分类号] R755 [文献标识码] A [文章编号] 1674-4721（2017）09（c）-0092-03

[Abstract]Objective To investigate the immune function in patients with leprelcosis.Methods 60 patients with leprelcosis in the Hongwei Hospital of Nanhai District in Foshan City and Centers for Disease Control and Prevention of Nanhai District in Foshan City from January 2016 to May 2017 were selected as the observation group，at the same time，60 leprosy patients without ulcer in the were selected as the control group，and 60 healthy people received physical examination were selected as healthy group.The levels of peripheral blood lymphocyte subsets （CD3+，CD3+CD4+，CD3+CD8+，CD16+CD56+，CD19+，CD4+/CD8+），immunoglobulin （Ig） in the three groups were detected respectively.Results The levels of CD3+，CD3+CD4+，CD3+CD8+，CD16+CD56+，CD19+，CD4+/CD8+ in the control group and healthy group were compared，there was no statistical difference （P>0.05）；The levels of CD3+，CD3+CD4+，CD3+CD8+，CD16+CD56+，CD4+/CD8+ in observation group were significantly lower than those in control group，but the level of CD19+ in observation group was higher than that in control group，with statistical difference （P<0.05）；The levels of IgG，IgA，IgM in the control group and healthy group were compared，there was no statistical difference （P>0.05）；Compared with the control group，the levels of IgG，IgA，IgM in the observation group were significantly increased，with statistical difference （P<0.05）.Conclusion The leprelcosis patients have excessive humoral immune responses.The decreased cellular immune function is associated with the occurrence and development of leprelcosis.

[Key words]Leprelcosis；Immune function；Lymphocyte subsets

麻風病是一种慢性传染病，由麻风分枝杆菌引起，一般有2～5年甚至长达10年的潜伏期[1]。麻风溃疡为麻风病常见的后遗症和并发症，臀部、四肢等受压部位为其好发位置，以足底溃疡最为多见，其发病率为10%～60%[2]。麻风溃疡可累及全身各层组织，包括皮肤、关节等，病情严重时可引起全足坏疽、缺失，对患者的生活质量造成严重的影响[3]。感染、局部受压、继发性损害等因素与麻风溃疡的发生有密切的关系。研究显示，机体免疫状态与麻风溃疡的发生有关[4]。本研究选择麻风、麻风溃疡及健康体检者为研究对象，分别对其淋巴细胞亚群和血清免疫球蛋白水平进行检测，分析麻风溃疡患者免疫功能情况。现将研究结果报道如下。endprint

1资料与方法

1.1一般资料

选择2016年1月～2017年5月在佛山市南海区红卫医院和佛山市南海区疾病预防控制中心门诊就诊的60例麻风溃疡患者为观察组，其中女20例，男40例；年龄……