孙贵祥　孙培丽　张芾

[摘要] 目的 观察与探讨依那普利叶酸片辅治H型高血压致急性脑梗死患者的临床效果。 方法 选取2015年12月～2017年1月期间于我院就诊及治疗的100例H型高血压致急性脑梗死患者作为研究对象，按照随机数字表法分为两组，每组各50例，对照组患者给予瑞舒伐他汀加硝苯地平缓释片治疗，观察组患者在对照组的基础上给予依那普利叶酸片辅治，对比并分析两组患者的效果。 结果 观察组患者治疗后MDA水平、SOD水平、NO水平、ET水平明显优于对照组，差异有统计学意义（P<0.05），观察组患者治疗后的血浆HCY水平、Barthel评分、NIHSS评分明显优于对照组，差异有统计学意义（P<0.05）。 结论 对H型高血压致急性脑梗死患者进行常规治疗的同时，增加使用依那普利叶酸片辅助治疗的效果更佳。

[关键词] 依那普利叶酸片；H型高血压；急性脑梗死

[中图分类号] R544.1；R743.3 [文献标识码] B [文章编号] 1673-9701（2017）23-0036-03

[Abstract] Objective To observe and explore the clinical effect of enalapril folate tablets in the auxiliary treatment of acute cerebral infarction caused by H-type hypertension. Methods A total of 100 patients with acute cerebral infarction caused by H-type hypertension who were diagnosed and treated in our hospital from December 2015 to January 2017 were selected as the study subjects. According to the random number table method， the patients were divided into two groups， with each group of 50 patients. Patients in the control group were treated with rosuvastatin plus nifedipine sustained-release tablets， and the patients in the observation group were treated with enalapril folate tablets on the basis of the control group. The effects of the two groups were compared and analyzed. Results The levels of MDA， SOD， NO and ET in the observation group after the treatment were significantly better than those in the control group， and the differences between groups were significant （P<0.05）. The levels of plasma HCY， Barthel score and NIHSS score in the observation group after the treatment were significantly better than those in the control group， and the differences between groups were significant（P<0.05）. Conclusion It is better to further apply enalapril folate tablets in the auxiliary treatment of acute cerebral infarction caused by H-type hypertension on the basis of the conventional treatment.

[Key words] Enalapril folate tablets； H-type hypertension； Acute cerebral infarction

H型高血壓是发生急性脑梗死的一个重要的独立危险因素，H型高血压容易使急性脑梗死的发病率提升，严重危害患者的机体健康和生命安全[1，2]。本文选取2015年12月～2017年1月于我院收治的100例患者作为研究对象，针对依那普利叶酸片辅治H型高血压致急性脑梗死患者的临床效果进行研究，现报道如下。

1 资料与方法

1.1 临床资料

选择2015年12月～2017年1月期间于我院接受治疗的100例H型高血压致急性脑梗死患者进行研究，根据随机数字表法分为两组，每组各50例。对照组中，男20例，女30例，年龄46～78岁，平均（57.25±1.46）岁；观察组中，男21例，女29例，年龄45～76岁，平均（57.27±1.44）岁。两组患者的性别比例、平均年龄、疾病类型与病情程度等资料比较，差异无统计学意义（P>0.05），具有可比性。

1.2 研究方法[3-5]

对照组患者应用瑞舒伐他汀加硝苯地平缓释片治疗，每天服用1次瑞舒伐他……