以多发性急性脑梗死为表现的Trousseau综合征临床及影像学特点分析
2017-10-17项正兵吴凌峰吴晓牧
黄 刚, 袁 敏, 项正兵, 吴凌峰, 吴晓牧
以多发性急性脑梗死为表现的Trousseau综合征临床及影像学特点分析
黄 刚, 袁 敏, 项正兵, 吴凌峰, 吴晓牧
目的探讨以多发性急性脑梗死为表现的Trousseau综合征临床、实验室检查及影像学特点。方法收集了11例以多发性急性脑梗死为表现的Trousseau综合征患者的临床资料、实验室检查、影像学资料,进行总结分析。结果11例患者男性4例,女性7例,年龄为45~80 岁;肺癌4例,肺癌伴肝转移2例,直肠癌1例,胰腺癌1例,胃癌2例,卵巢癌1例;D-二聚体为10.11~40.56 mg/L,平均为29.10 mg/L;头磁共振表现为多个动脉支配区的多发性脑梗死。结论肿瘤相关性多发性急性脑梗死是Trousseau综合征的一种表现形式,其表现特点为累及多个动脉支配区的多发性急性脑梗死伴有血D-二聚体显著升高,这些特征性表现可以作为隐匿性癌症的线索之一。
Trousseau综合征; 脑梗死; 恶性肿瘤; 磁共振
Abstract:ObjectiveTo investigate the clinical,laboratory and imaging features of Trousseau syndrome with multiple acute cerebral infarction.Methods11 cases of Trousseau syndrome with multiple acute cerebral infarction were collected. The clinical data,laboratory examination and imaging data were collected and analyzed.ResultsThere were 4 cases of male and 4 cases of female,aged 45~80 years;4 cases of lung cancer,2 cases of lung cancer with liver metastasis,1 case of rectal cancer,1 case of pancreatic cancer,2 cases of gastric cancer,1 case of ovarian cancer;D-dimer was 10.11~40.56 mg / L with an average of 29.10 mg/L;head magnetic resonance showed multiple cerebral infarctions in the arterial innervation region.ConclusionTumor-related multiple acute cerebral infarction is a manifestation of Trousseau syndrome,which is characterized by a significant increase in multiple D-dimer associated with acute cerebral infarction involving multiple arterial areas. These features Performance can be used as one of the clues to occult cancer.
Keywords: Trousseau syndrome; Cerebral infarction; Malignancy; Magnetic resonance
肿瘤相关性多发性急性脑梗死是Trousseau综合征的一种表现形式,其产生与潜在恶性肿瘤相关。其表现多种多样,急性脑梗死可以为单发病灶,也可以为单个动脉支配区多发病灶或多个动脉支配区的多发病灶。近年来越来越多以多个动脉支配区的多发病灶急性脑梗死的Trousseau综合征病例被发现并报道,且已报道的病例多与胃癌,肺癌,胰腺癌和卵巢癌等肿瘤有关。现收集了11例我院神经内科诊治的以多发性急性梗死为表现的Trousseau综合征患者的临床病例资料并分析如下。
1 对象与方法
1.1 一般资料 11例患者均来自于2012年1月~2017年1月……
