王淑梅，于金凤

（牡丹江医学院附属红旗医院，黑龙江 牡丹江 157011）

不同剂量米非司酮用于围绝经期子宫肌瘤诱导绝经效果比较

王淑梅，于金凤

（牡丹江医学院附属红旗医院，黑龙江 牡丹江 157011）

目的分析不同剂量米非司酮用于围绝经期子宫肌瘤诱导绝经的效果。方法 选择医院2015年4月至2016年4月收治的围绝经期子宫肌瘤患者76例，按随机数字表法分为大剂量治疗组（A组）和小剂量治疗组（B组），各38例。A组采用大剂量米非司酮（25．0mg／d）治疗，B组采用小剂量米非司酮（12．5mg／d）治疗。结果 干预后，B组绝经成功率明显高于A组，不良反应发生率明显低于A组（P＜0．05）；干预后，两组患者子宫体积、子宫肌瘤体积、血红蛋白水平均显著改善（P＜0．05）。结论 不同剂量（25．0mg／d和12．5mg／d）米非司酮治疗围绝经期子宫肌瘤诱导绝经效果确切，可有效缩小子宫和子宫肌瘤体积，升高血红蛋白水平，且小剂量（12．5mg／d）米非司酮诱导绝经成功率更高，安全性更好，故可将12．5mg／d作为米非司酮用于围绝经期子宫肌瘤诱导绝经的最佳剂量。

剂量；米非司酮；围绝经期；子宫肌瘤；诱导绝经；临床疗效

Abstract：Objective To analyze the effect of different doses of mifepristone for inducing menopause in patients with hysteromyoma in perimenopausal period．M ethods Totally 76 women with hysteromyoma in perimenopausal period admitted to our hospital from April 2015 to April 2016 were divided into the high dose group（group A）and the low dose group（group B）according to the random number table，38 cases in each group．The group A was treated with high dose mifepristone（25．0 mg／d），and the group B was treated with low dose mifepristone（12．5 mg／d）．Resu lts After the intervention，the success rate of menopause in group B was significantly higher than that in group A，and the incidence rate of adverse reaction in group B was significantly lower than that in group A （P ＜0．05）．After the intervention，the volume of uterus，the volume of hysteromyoma and the level of hemoglobin of the two groups were significantly improved（P＜0．05）．Conclusion Different doses（25．0 mg／d and 12．5 mg／d）of mifepristone in induction of menopause in patients with hysteromyoma in perimenopausal period has good effect，it can effectively reduce the volume of uterus and hysteromyoma，increase the hemoglobin level，and achieve a higher success rate and safety of menopause with low dose（12．5 mg／d）mifepristone，so the 12．5 mg／d can be regarded as the optimal dose of mifepristone for inducing menopause in patients with hysteromyoma in perimenopausal period．

Key words：doses；mifepristone；perimenopausal period；hysteromyoma；induction of menopause；clinical effect

围绝经期是卵巢功能衰退至绝经后1年这段时间，在此期间，女性雌、孕激素水平和生理状态可发生明显变化，易出现各种生殖系统病变[1]。女性常见的良性肿瘤子宫肌瘤多发生于该期，可表现为下腹包块、排尿困难和月经异常等，多数患者因缺乏典型症状不能尽早确诊而延误早期治疗，存在较大的病情加重的风险[2]。为此，本研究中探讨了不同剂量米非司酮用于围绝经期子宫肌瘤诱导绝经的效果，报报道如下。……