于姣+何瑾瑜+陈捷+张蕾

[摘要] 目的 观察乐脉丸对冠心病心绞痛患者Ghrelin/obestatin比值的影响及临床疗效。 方法 将80例冠心病心绞痛患者随机分为观察组（n=40）和对照组（n=40），对照组采用辛伐他汀、硝酸异山梨酯片、阿司匹林常规西医治疗，观察组在对照组的基础上加用乐脉丸治疗，两组治疗时间均为1个月。采用酶联免疫吸附试验检测Ghrelin、obestatin水平，并比较治疗前后水平变化。 结果 治疗后，观察组患者的治疗总有效率显著高于对照组，差异具有统计学意义（P<0.01）。治疗后，观察组患者的心绞痛发作次数、持续时间及硝酸甘油用量显著均低于对照组，差异均有统计学意义（P<0.01）。治疗后，观察组患者Ghrelin/obestatin比值明显高于对照组，差异有统计学意义（P<0.05）。 结论 乐脉丸治疗冠心病心绞痛疗效明显，对冠心病心绞痛的发作有一定的保护作用，能增加Ghrelin/obestatin比值。

[关键词] 乐脉丸；冠心病心绞痛；Ghrelin/obestatin比值；影响

[中图分类号] R541.4 [文獻标识码] B [文章编号] 1673-9701（2017）22-0110-03

[Abstract] Objective To observe the effect of Lemai pill on Ghrelin/obestatin ratio in coronary heart disease patients with angina pectoris and its clinical curative effect. Methods 80 cases of coronary heart disease patients with angina pectoris were randomly divided into two groups including observation group（n=40） and control group（n=40）. The control group was treated with conventional western medicine including simvastatin， isosorbide dinitrate tablets and aspirin. The observation group was added with Lemai pill based on the treatment of the control group. The treatment time of two groups was one month. Ghrelin and obestatin levels were measured by enzyme-linked immunosorbent assay（ELISA）， and the changes were observed before and after treatment. Results After treatment， the total effective rate of the observation group was significantly higher than that of the control group， and the difference was statistically significant（P<0.01）. After treatment， the number of angina attacks， duration and nitroglycerin dosage in the observation group were significantly lower than those in the control group， and the difference between the two groups was significant（P<0.01）. After treatment， the ratio of Ghrelin/obestatin in the observation group was significantly higher than that in the control group， and the difference was statistically significant（P<0.05）. Conclusion Lemai pill is obviously effective in the treatment of coronary heart disease with angina pectoris， which has a protective effect on the onset of coronary heart disease angina and can increase the ratio of Ghrelin/obestatin.

[Key words] Lemai pill； Coronary heart disease angina； Ghrelin/obestatin ratio； Effect

冠心病心绞痛是冠状动脉供血不足、心肌急剧、暂时缺血与缺氧所引起的临床综合征[1]，是临床上的多发病、常见病。冠心病属于中医“胸痹”“心痛”“真心痛”等范畴，而其致病机制是本虚标实[2]。目前临床上治疗冠心病心绞痛仍以西药为主，但西药存在不良反应多的弊端，而中成药能降低不良反应[3]。乐脉丸是由赤芍、丹参、川芎、香附、红花、木香和山楂等7种中药研制而成，具有行气活血、化瘀通脉等效果[4]。本文旨在研究乐脉丸治疗对冠心病心绞痛患者的临床疗效和Ghrelin/obestatin比值的变化，探讨乐脉丸治疗冠心病心绞痛的临床应用价值。endprint

1资料与方法

1.1 一般资料

选取2012年1月～2016年6月在我院和余姚市人民医院诊治的冠心病心绞痛患者80例作为研究对象。冠心病心绞痛分级依据为加拿大心绞痛严重度分级标准[5]。采用随机数字表法分为对照组和观察组各40例，其中对照组男26例，女14例；……