廖新媛++李金成

[摘要]目的 研究左氧氟沙星治療急性肾盂肾炎的效果。方法 选取2015年3月～2017年3月来我院就诊的50例急性肾盂肾炎患者，随机分为对照组和观察组，各25例。对照组给予美洛西林治疗，观察组给予左氧氟沙星治疗，比较两组的治疗总有效率、不良反应发生率以及临床症状缓解时间。结果 观察组的治疗总有效率为95.0%，高于对照组的75.0%（P<0.05）；观察组的临床症状缓解时间（退热时间、肾区叩痛缓解时间、腰痛缓解时间和膀胱刺激症状缓解时间）均短于对照组（P<0.05）；两组的用药不良反应发生率比较，差异无统计学意义（P>0.05）。结论 左氧氟沙星治疗急性肾盂肾炎的效果确切，能快速缓解患者的临床症状，促进患者康复，且用药安全性高，值得推广。

[关键词]左氧氟沙星；美洛西林；急性肾盂肾炎；临床症状

[中图分类号] R692.3 [文献标识码] A [文章编号] 1674-4721（2017）07（c）-0075-03

Clinical efficacy of Levofloxacin in the treatment of acute pyelonephritis

LIAO Xin-yuan LI Jin-cheng

Department of Nephrology，People′s Hospital of Yunfu City in Guangdong Province，Yunfu 527300，China

[Abstract]Objective To study the effect of Levofloxacin in the treatment of acute pyelonephritis.Methods From March 2015 to March 2017，50 patients with acute pyelonephritis in our hospital were selectad and randomly divided into the control group and the observation group，25 cases in each group.The control group was treated with Metoprolol，and the observation group was treated with Levofloxacin.The total efficiency，the incidence rate of adverse reactions and the remission time of clinical symptoms in both groups were compared.Results The total effective rate in the observation group was 95.0%，which was higher than 75.0% in the control group （P<0.05）.The remission time of the clinical symptoms （the time of fever，the time of percussion pain，the relief time of the lumbago and the remission time of bladder irritation symptoms） in the observation group was shorter than that in the control group （P<0.05）.There was no significant difference in the incidence rate of adverse drug reactions between the two groups （P>0.05）.Conclusion Levofloxacin is effective in the treatment of acute pyelonephritis，which can quickly relieve the clinical symptoms，promote the recovery of patients，and is worth popularizing.

[Key words]Levofloxacin；Mezlocillin；Acute nephritis；Clinical symptoms

急性肾盂肾炎指的是发病于肾盂黏膜、肾实质的炎症反应疾病，一般由大肠杆菌感染引起[1]，也有部分患者是由葡萄球菌、变形杆菌、粪链球菌等感染引起，主要症状表现为腰痛、肾区叩痛、寒战、发热等[2-3]。由于急性肾盂肾炎侵袭到肾小管、肾实质、肾间质等多个部位，病情进展快，不及时治疗可能诱发肾功能衰竭等严重后果，也可能发展成为慢性肾炎[4]，不利于患者生存质量的提高。我院对急性肾盂肾炎患者应用左氧氟沙星治疗取得了满意的效果，现报道如下。

1 资料与方法

1.1一般资料

选取2015年3月～2017年3月我院收治的50例急性肾盂肾炎患者，均符合《内科学》中关于急性肾盂肾炎的相关诊断标准，均伴有不同程度的肾区叩痛、发热、腰痛、膀胱刺激症状；患者均知情同意，签署知情同意书。将入选患者随机分为对照组和观察组，各25例。……