陈海兵

[摘要] 目的 探讨家族性渗出性玻璃体视网膜病变（familial exudative vitreoretinopathy，FEVR）的荧光素眼底血管造影（fluorescein fundus angiography，FFA）效果。方法 选取2012年1月～2016年12月我院收治的家族性渗出性玻璃体视网膜病变患儿34例68眼为研究组，选取同期健康小儿34例68眼为对照组，两组研究对象均应用荧光素眼底血管造影诊断。结果 研究组34例患儿68只眼中，正常眼3只，占4.4%，1期眼4只，占5.9%，2期眼7只，占10.23%，3期眼2只，占2.9%，4期眼8只，占11.8%；5期眼44只，占64.7%。两组在CRA血流参数方面对比，研究组的PSV及EDV低于对照组，同时RI高于对照组，差异均有统计学意义（P<0.05）；两组在PCA血流参数方面对比，研究组PSV及EDV低于对照组，同时RI高于对照组，差异均有统计学意义（P<0.05）；两组在OA血流参数方面对比，研究组PSV及EDV低于对照组，同时RI高于对照组，差异均有统计学意义（P<0.05）。结论 荧光素眼底血管造影诊断家族性渗出性玻璃体视网膜病变的效果理想，能够为临床治疗提供参考。

[关键词] 家族性渗出性玻璃体视网膜病变；荧光素眼底血管造影；诊断；分期；血流动力学

[中图分类号] R744.1 [文献标识码] B [文章编号] 1673-9701（2017）19-0072-04

[Abstract] Objective To investigate the effect of fluorescein fundus angiography（FFA） on familial exfoliating vitreoretinopathy （FEVR）. Methods 34 children （68 eyes） with pediatric exudative vitreous retinopathy admitted in our hospital from January 2012 to December 2016 were chosen as the study group. 34 healthy children in the same period were selected as the control group. Two groups of subjects were treated with fluorescein fundus angiograph for diagnosis. Results In the study group of 34 children with 68 eyes， there were 3 normal eyes （4.4%）， 4 eyes at stage 1 （5.9%）， 7 eyes at stage 2 （10.23%）， 2 eyes at stage 3 （2.9%）， 8 eyes at stage 4 （11.8%）， 44 eyes at stage 5 （64.7%）. In comparison of CRA blood flow parameters between the two groups， the PSV and EDV of the study group were lower than those of the control group， and the RI in the study group was higher than that in the control group. The differencs were satistically significant （P<0.05）. In comparison of PCA blood flow parameters between the two groups， the PSV and EDV of the study group were lower than those of the control group， and the RI in the study group was higher than that in the control group. The differencs were satistically significant （P<0.05）. In comparison of OA blood flow parameters between the two groups， the PSV and EDV of the study group were lower than those of the control group， and the RI in the study group was higher than that in the control group. The differencs were satistically significant（P<0.05）. Conclusion Fluorescein fundus angiography is effective in the diagnosis of familial exudative vitreoretinopathy and can provide a reference for clinical treatment.

[Key words] Familial exudative vitreoretinopathy； Fluorescein fundus angiography； Diagnosis； Staging； Hemodynamics

家族性渗出性玻璃体视网膜病变（familial exudative vitreoretinopathy，FEVR）在上世纪六十年代报道并命名，患儿的临床表现及遗传方式呈现出多元化的特点，往往会同时侵犯双眼，是视网膜脱离的重要诱因。研究显示FEVR的眼底表现为新生血管及视网膜无灌注。如果患儿病情轻微同时无血管的区域较小，患儿往往不会出现视力问题，因此眼底检查容易出现误诊及漏诊问题[1]。荧光素眼底血管造影（fluorescein fundus angiography，FFA）檢查能够明确病变的情况从而提示病情发展，不过在眼底疾病检查中的应用还不够广泛。本研究应用FFA诊断FEVR患儿，现报道如下。

1 资料与方法

1.1 一般资料

选取2012年1月～2016年12月我院收治的家族性渗出性玻璃体视网膜病变患儿34例68眼为研究组，男22例，女12例，年龄1～13岁，平均（8.1±0.4）岁。纳入标准：患儿有FEVR家族史；均属于足月儿，同时出生体重正常；至少1只眼出现视网膜无灌注以及视网膜下渗出等问题。……