刘志勇++++++孟毅++++++常学辉++++++郭健++++++乔明亮++++++赵丽娜

[摘要] 目的 探討柴石退热颗粒对流行性乙型脑炎病毒CQ11-66的影响。 方法 选取2015年5月～2016年12月在河南省中医院住院的流行性乙型脑炎患者150例，按随机数字表法将其分为两组，各75例。对照组行常规综合治疗，观察组在对照组基础上加用柴石退热颗粒。两组均治疗15 d。治疗后观察两组临床疗效以及症状改善时间，比较两组患者住院时间以及治疗前后血清中神经元特异性烯醇化酶（NSE）、过氧化脂质（LPO）、白细胞介素-2（IL-2）含量。 结果 观察组痊愈率明显高于对照组，差异有统计学意义（P < 0.05），观察组总有效率虽高于对照组，但差异无统计学意义（P > 0.05）。观察组体温恢复正常时间、神智恢复正常时间及头痛、呕吐、抽搐缓解时间均明显短于对照组，差异均有统计学意义（P < 0.05）。观察组平均住院时间明显短于对照组，差异有统计学意义（P < 0.05）。治疗后，两组患者血清中NSE、LPO含量均明显低于治疗前，IL-2含量明显高于治疗前，差异均有统计学意义（P < 0.05）。但两组治疗后血清中NSE、LPO、IL-2含量比较差异均无统计学意义（P > 0.05）。 结论 柴石退热颗粒对流行性乙型脑炎病毒CQ11-66有明显的治疗效果，能够明显缩短患者住院时间，加快症状改善，有效减轻患者痛苦，值得广泛推广。

[关键词] 柴石退热颗粒；流行性乙型脑炎病毒；CQ11-66；疗效

[中图分类号] R512.32 [文献标识码] A [文章编号] 1673-7210（2017）06（a）-0078-04

Effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66

LIU Zhiyong1 MENG Yi1 CHANG Xuehui1 GUO Jian1 QIAO Mingliang1 ZHAO Li'na2

1.Department of Encephalopathy， He'nan Traditional Chinese Medicine Hospital， He'nan Province， Zhengzhou 450002， China； 2.Department of Traditional Chinese Medicine， Zhengzhou Children's Hospital， He'nan Province， Zhengzhou 450053， China

[Abstract] Objective To investigate the effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66. Methods One hundred and fifty patients with epidemic encephalitis B hospitalized in He'nan Traditional Chinese Medicine Hospital from May 2015 to December 2016 were selected and divided into two groups by random number table method， with 75 cases in each group. The control group was treated with routine comprehensive treatment， on basis of control group， the observation group was added with Chaishi Tuire Granules. Both groups were treated for 15 days. After treatment， the clinical efficacy and symptom improvement time of the two groups were observed， the hospital stay and the contents of serum neuron-specific enolase （NSE）， lipid peroxidase （LPO）， interleukin-2 （IL-2） before and after treatment between the two groups were compared. Results The cure rate in the observation group was significantly higher than that in the control group， the difference was statistically significant （P < 0.05）， the total effective rate in the observation group was higher than that in the control group， but the difference was not statistically significant （P > 0.05）. The time of body temperature returned to normal， time of intelligence returned to normal， and the relief time of headache， vomiting， convulsions in the observation group was all shorter than those of control group， the differences were all statistically significant （P < 0.05）. The average hospital stay of observation group was shorter than that of control group， the difference was statistically significant （P < 0.05）. After treatment， the contents of serum NSE， LPO in the two groups were all lower than those before treatment， the contents of IL-2 were higher than those before treatment， the differences were all statistically significant （P < 0.05）. But there were no statistically significant differences of the contents of serum NSE， LPO， IL-2 after treatment between the two groups （P > 0.05）. Conclusion Chaishi Tuire Granules has obvious therapeutic effect for epidemic encephalitis B virus CQ11-66， which can obviously shorten hospital stay， speed up the improvement of symptoms， relieve the pain of patients effectively， it is worthy of extensive promotion.

[Key words] Chaishi Tuire Granules； Epidemic encephalitis B virus； CQ11-66； Efficacy

流行性乙型脑炎又称日本乙型脑炎，简称乙脑，是一种急性中枢系统性传染病[1]，有较高的发病率及致死率，即使接受治疗也有大部分患者留下中枢神经系统后遗症。目前为止，乙型脑炎的系统治疗方法并不是很多，一般大多数采取单独西药治疗，效果并不显著。本研究将柴石退热颗粒用于流行性乙型脑炎的治疗中，取得了较好的效果，现报道如下：

1 资料与方法

1.1 一般资料

选取2015年5月～2016年12月河南省中医院脑病科收治的流行性乙型脑炎患者150例作为研究对象。……