林武壮?梁土金?李明海

[摘要] 目的 分析研究血浆脂蛋白相关磷脂酶A2水平对进展性脑梗死的预测价值。 方法 选取我院在2015年3月～2016年7月收治的84例急性脑梗死患者作为本次研究的观察组，另选择46例健康志愿者作为本次研究的对照组。给予观察组患者进行卒中量表（NIHSS）评分和血浆脂蛋白相关磷脂酶A2（Lp-PLA2）水平的检验；对照组进行血浆Lp-PLA2水平的检验。 结果 在84例急性脑梗死患者中，有40例为进展性脑梗死（进展性脑梗死组），有44例为稳定性脑梗死（稳定性脑梗死组）。观察组患者的血浆Lp-PLA2水平均显著高于对照组，差异具有统计学意义（P<0.05）。进展性脑梗死组的血浆Lp-PLA2水平明显高于稳定性脑梗死组，差异具有统计学意义（P<0.05）。 结论 血浆Lp-PLA2水平的高低与脑梗死的严重程度有着较大的关系，可作为预测进展性脑梗死的重要临床依据。

[关键词] 进展性脑梗死；血浆Lp-PLA2水平；预测价值；卒中量表

[中图分类号] R743.3 [文献标识码] A [文章编号] 2095-0616（2017）09-233-03

Predictive value of plasma lipoprotein associated phospholipase A2 to progressive cerebral infarction

LIN Wuzhuang LIANG Tujin LI Minghai

CITIC Huizhou Hospital，Huizhou 516006，China

[Abstract] Objective To analyze the pridictive value of plasma lipoprotein associated phospholipase A2 to progressive cerebral infarction. Methods 84 patients with acute cerebral infarction cured in our hospital from March 2015 to July 2016 were slected as the observation group，and 46 cases of healthy volunteers were selected as the control group.Patients in observation group were treated with stroke Scale （NIHSS） score and plasma lipoprotein associated phospholipase A2 （Lp-PLA2） levels.Volunteers in control group were treated with plasma Lp-PLA2 level test. Results In 84 patients with acute cerebral infarction，there were 40 cases of progressive cerebral infarction （progressive cerebral infarction group），and there were 44 cases of stable cerebral infarction （stable cerebral infarction group）.The plasma Lp-PLA2 level of the observation group was significantly higher than that of the control group，the difference was statistically significant（P<0.05）.The level of plasma Lp-PLA2 in patients with progressive cerebral infarction was significantly higher than that in stable cerebral infarction group，the difference was statistically significant （P<0.05）. Conclusion The level of plasma Lp-PLA2 was significantly related to the severity of cerebral infarction.It can be used as an important basis for the prediction of progressive cerebral infarction.

[Key words] Progressive cerebral infarction；Plasma Lp-PLA2 level；Predictive value；Stroke scale

急性腦梗死属于人体脑部血液循环障碍性疾病，临床上也称之为缺血性脑卒中，可分为进展性脑梗死和稳定性脑梗死，具有起病急、治疗难度大、预后不佳等特点[1-2]。其中，进展性脑梗死患者的死亡率以及致残率都要比稳定性脑梗死患者高出许多。因此，给予进展性脑梗死患者及时的确诊以及高效的治疗有着重要的意义[3]。从以往的研究报道中可知，脑梗死的起病原因和病理过程都与炎症息息相关。除了已知的CRP和PCT等炎性反应标志物外，Lp-PLA2也与炎症的产生有着密切关系，Lp-PLA2作为一种新型的炎性反应标志物，其参与了血管发生动脉粥样硬化的全过程[4]。因此，本文将进一步研究Lp-PLA2水平高低与进展性脑梗死患者病情严重程度的联系，分析其对疾病的预测价值。……