李晓坚?劳日初?陈庞洲

[摘要] 目的 研究分析肉芽肿性小叶性乳腺炎改良综合治疗的临床经验。 方法 选取2015年1月～2016年4月入组符合一期手术指征的肉芽肿性小叶性乳腺炎患者30例。根据随机数字表法分为观察组及对照组各15例。两组均给予常规手术治疗，对照组在此基础上予以术前新辅助治疗，观察组则在此基础上行围手术期序贯治疗。分别比较两组临床治愈率、复发率、并发症发生情况、住院时间及患者满意度。 结果 两组临床治愈率、复发率比較，无统计学意义（P>0.05）。观察组并发症发生率为20%（3/15），与对照组比较，13.33%（2/15）比较，差异无统计学意义（P>0.05）。观察组住院时间为（4.4±2.4）d，与对照组的（5.0±2.6） d比较，差异无统计学意义（P>0.05）。两组患者满意度，观察组93%（14/15），对照组67%（10/15）比较，差异有统计学意义（P<0.05）。 结论 类固醇激素类药物配合手术的围手术期序贯综合治疗应用于肉芽肿性小叶性乳腺炎中的初步临床经验治疗效果较佳，有临床推广应用价值。

[关键词] 肉芽肿性小叶性乳腺炎；综合治疗；复发率

[中图分类号] R655.8 [文献标识码] A [文章编号] 2095-0616（2017）09-176-04

Clinical experience of modified combined therapy of granulomatous lobular mastitis

LI Xiaojian1 LAO Richu1 CHEN Pangzhou2

1.Department of Surgery，the Sixth Peoples Hospital of Nanhai，Foshan 528248，China；2.Department of General Surgery，Nanhai Peoples Hospital，Foshan 528000，China

[Abstract] Objective To explore the clinical experience of modified combined therapy of granulomatous lobular mastitis. Methods 30 cases of granulomatous lobular mastitis undicated for primary surgery from January 2015 to April 2016 were selected and divided into observation group and control group with 15 cases in each according to random digital table method.All the patients were treated with routine surgical treatment，patients in control group were treated with preoperative neoadjuvant therapy on the basis of routine surgical treatment，and patients in observation group were treated with perioperative sequential therapy on the basis of routine surgical treatment.Clinical cure rate，recurrence rate，complications，hospital stay and patient satisfaction of the two groups were compared. Results There was no significant difference between the two groups in clinical cure rate and recurrence rate （P>0.05）.The complication rate of the observation group was 20% （3/15），and the control group was 13.33% （2/15），there was no significant difference between the two groups （P>0.05）.The hospitalization time of the observation group was （4.4+2.4）d，and the control group was （5.0±2.6）d，there was no significant difference between the two groups （P>0.05）.The patients satisfaction of observation group was 93% （14/15），the control group was 67% （10/15），there was a significant difference （P<0.05）. Conclusion Preliminary clinical effect of combined sequential therapy of steroid hormone drugs in perioperative period in treatment of granulomatous lobular mastitis is good.It has the clinical application value.

[Key words] Granulomatous lobular mastitis；Combined treatment；Recurrence rate

肉芽肿性小叶性乳腺炎是临床上较为罕见的一种炎性疾病，其主要是由特异性因素引发，且该病多发见于育龄期女性[1]。其中乳腺小叶来源的慢性肉芽肿性炎症时其标志性的病理改变[2]。迄今为止，临床上对该病的发病机制尚未完全清楚，但学者认为与自身免疫存在密切相关，国内外对于该病的治疗也尚未达成共识[3]。鉴于此，本文通过研究分析肉芽肿性小叶性乳腺炎改良综合治疗的临

床经验，目的在于为临床有效治疗该病提供参考依据，现报道如下。

1 资料与方法

1.1 一般资料

选取2015年1月～2016年4月入组符合一期手术指征的肉芽肿性小叶性乳腺炎患者30例。所有患……