彭莉

[摘要]目的 探讨地西他滨联合预激方案治疗老年骨髓增生异常综合征的临床效果。方法 选择2012年6月～2017年1月本院收治的55例老年骨髓增生异常综合征患者作为研究对象，并对所有患者进行数字编号和随机分组，分为两组，对照组30例，观察组25例。对照组患者采用预激方案治疗，观察组采用地西他滨联合预激方案治疗。比较两组患者治疗后的临床效果。结果 观察组患者的总有效率（96.00%）显著高于对照组（66.67%），观察组患者的治疗效果更好（P<0.05）。观察组患者肝功能受损、血小板降低、粒细胞减少的不良反应发生率显著低于对照组（P<0.05）。結论 地西他滨联合预激方案治疗老年骨髓增生异常综合征具有明显的效果，有利于消除患者的临床症状，促使其尽快恢复，具有重要的临床价值。

[关键词]地西他滨；预激方案；老年骨髓增生异常综合征；临床效果

[中图分类号] R551.3 [文献标识码] A [文章编号] 1674-4721（2017）06（c）-0025-03

[Abstract]Objective To evaluate the clinical effect of Decitabine combined with pre-excitation regimen in the treatment of senile myelodysplastic syndrome.Methods 55 elderly patients with myelodysplastic syndrome who were admitted into our hospital from June 2012 to January 2017 were selected as the study objects.All patients were numbered and randomly divided into two groups，and there were 30 patients in the control group，and 25 patients in the observation group.The patients in the control group were given pre-excitation regimen，while the observation group was given Decitabine combined with pre-excitation regimen.The clinical efficacy of patients between the two groups after treatment were compared.Results The total effective rate was 96.00% in the observation group，which was significantly higher than that in the control group （66.67%） and the observation group had a better curative effect （P<0.05）.The incidence of adverse reactions such as impaired liver function，thrombocytopenia and granulocytopenia in the observation group was significantly lower than those in the control group （P<0.05）.Conclusion Clinical effect of Decitabine combined with pre-excitation regimen in the treatment of senile myelodysplastic syndrome has a significant effect，which is helpful to eliminate the clinical symptoms of patients and promote the recovery of patients as soon as possible，and has an important clinical value.

[Key words]Decitabine；Pre-excitation regimen；Senile myelodysplastic syndrome；Clinical effect

老年骨髓增生异常综合征主要是指老年患者因为多能造血干细胞的恶性克隆性所表现出的疾病，患者若没有接受及时有效的治疗将会发展为急性白血病，严重危害其健康和生活[1-2]。此外老年患还常伴随其他慢性疾病，抵抗力较弱，若采用刺激性过大的治疗方法，则难以保证治疗[3]。本研究选择本院收治的55例老年骨髓增生异常综合征患者为研究对象，探讨地西他滨联合预激方案治疗老年骨髓增生异常综合征的临床效果。

1 资料与方法

1.1 一般资料

选择2012年6月～2017年1月本院收治的55例老年骨髓增生异常综合征患者进行分析，所有患者均了解本研究内容及目的，并自愿签署知情同意书。采用数字编号和随机分组方式将55例患者分为对照组与观察组。对照组共30例，男性患者19例，女性患者11例，年龄为57～77岁，平均（62.13±0.82）岁；观察组共25例，男性患者13例，女性患者12例，年龄为56～77岁，平均（62.52±0.71）岁。……