姚晓艳　周中成　尉国莲

[摘要] 目的 觀察护理干预在胆结石合并慢性胃炎患者中的护理效果及对炎症因子的影响。 方法 选择本院收治的胆结石合并慢性胃炎患者70例，随机分为对照组（n=35）和观察组（n=35）。对照组采用常规方法护理，观察组在对照组基础上采用联合护理干预，采用酶联免疫吸附试验测定两组护理前、后转化生长因子β（TGF-β）、白细胞介素-2（IL-2）及白细胞介素-6（IL-6）水平，比较两组护理效果及对炎症因子的影响。 结果 观察组护理总满意度（97.14%）显著高于对照组（80.00%），两组比较差异有统计学意义（P<0.05）；两组护理前TGF-β、IL-2及IL-6水平比较，差异无统计学意义（P>0.05）；观察组护理后TGF-β、IL-2及IL-6水平显著低于对照组（P<0.05）；观察组护理后并发症发生率为5.71%，对照组为8.57%，两组护理后并发症发生率比较，差异无统计学意义（P>0.05）。 结论 胆结石合并慢性胃炎患者治疗过程中在常规护理基础上采用联合护理干预效果理想，能降低炎症因子水平，值得推广应用。

[关键词] 护理干预；胆结石；慢性胃炎；炎症因子

[中图分类号] R473.3 [文献标识码] B [文章编号] 1673-9701（2017）16-0134-04

[Abstract] Objective To observe the effect of nursing intervention in the patients with gallstones complicated with chronic gastritis and its effect on inflammatory factors. Methods A total of 70 patients with gallstones complicated with chronic gastritis who were admitted to our hospital were collected. They were randomly divided into the control group （n=35） and the observation group（n=35）. The control group was given conventional nursing methods， and the observation group was given combined nursing intervention on the basis of the control group. The levels of transforming growth factor-β （TGF-β）， interleukin-2 （IL-2） and interleukin-6 （IL-6） were determined by enzyme-linked immunosorbent assay （ELISA） before and after the nursing in both groups. The nursing effects and the effects on inflammatory factors were compared between the two groups. Results The total nursing satisfaction in the observation group （97.14%） was significantly higher than that in the control group（80.00%）， and there was statistically significant difference between the two groups（P<0.05）； there was no statistically significant difference in TGF-β， IL-2 and IL-6 levels between the two groups before the nursing （P>0.05）； the levels of TGF-β， IL-2 and IL-6 in the observation group were lower than those in the control group after the nursing（P<0.05）； the incidence rate of complications in the observation group was 5.71%， and the incidence rate was 8.57% in the control group. There was no statistically significant difference in the incidence rate of complications between the two groups after the nursing（P>0.05）. Conclusion The combined nursing intervention on the basis of regular nursing care for the patients with gallstones complicated with chronic gastritis has an ideal effect， which can reduce the level of inflammatory factors and is worthy of promotion and application.

[Key words] Nursing intervention； Gallstones； Chronic gastritis； Inflammatory factors

慢性萎缩性胃炎是临床常见疾病，属于慢性且难愈性疾病，具有病程长、癌变率高等特点，患者发病后临床上表现以腹胀、腹泻、恶心呕吐、食欲不强等为主。胆结石也是临床常见疾病，患者发病后临床表现厌食油腻、右腹部、左肩部疼痛为主[1]。当胆结石合并慢性胃炎后两种疾病相互影响，加重疾病的發生、发展，患者发病后如果得不到及时有效的治疗，将会诱发其他疾病，影响患者健康。常规护理虽然能满足治疗需要，但是护理缺乏针对性，未充分考虑每一位患者实际需要，导致护理预后较差，难以达到预期的护理效果[2，3]。……