杨岩涛+李森+刘金玲+周晋+周逸群+陈乃宏+贺福元

[摘要] 中药复方疗效是建立在单味中药基础上按中医药基础理论依法遣药组方治病的结果，其作用体现多成分、多靶点、综合效应的特点，其物质基础研究不易，质量标准难以建立，质量标志物难确定，无法严格监控中药加工全过程中的质量，且中药标志物的确定对中药药效物质研究、中药材鉴别及中药制药工程等影响深远；中药与生物体的“网通虹势”代谢规律将中药多成分的零散作用规律视为同母核群体的整体作用，可沟通微观单成分个体与宏观成分群整体，揭示中药在生物体内代谢物质、信息交流基本规律，进而揭示中药复方对人体的作用规律。通过系统分析中药质量标志物对中药开发的指导作用及其与“网通虹势”代谢规律的关系，尝试为中药质量标志物的确定提供思路。

[关键词] 中药质量标志物；网通虹势；药效物质；质量

[Abstract] The effect of Chinese medicine （CM） compound prescription is the combined action results of single herbs based on the basic theory of Chinese medicine， and its function embodies the characteristics of multi components， multi targets and comprehensive effects. It is difficult to study the therapeutic material， establish quality standards or determine Q-marker， so we can′t strictly monitor the quality of the whole process of CM. The identification of Q-marker has a profound influence on the whole process of the pharmaceutical engineering of CM. The scattered effect of CM multi-components is regarded as the integral action of the parent nucleus group by the metabolic rule of co-network compatibility and rainbow potential （CCRP）. The rule can be used to communicate the individual components and macro components， to reveal the metabolism of CM in organism body and basic law of information exchange， thus revealing the action law of CM on human body. Through the systematic analysis of the Q-marker′s guidance to the development of CM and its relationship with the metabolic rule of CCRP， we try to provide some ideas for the identification of Q-marker.

[Key words] Q-marker； co-network compatibility and rainbow potential； therapeutic material； quality

中药复方不仅是中医治病的物质基础，更是中医药基本理论的物质载体，中药复方的作用机制亦是实现中医药现代化的关键问题之一，中药复方疗效是建立在单味中药基础上按中医药基础理论依法遣药组方治病的结果，亦是单味中药有效成分群相互配伍，多靶点、多层次综合作用的结果，因此要阐明中药复方作用机制，首先就要回答中药多成分进入体内的代谢规律问题，阐明复方成分在体内吸收、分布、代谢、排泄诸环节的药效动力学与药物动力学规律；……