张扬　邓森　朱学嘉

【摘要】 目的：分析髋部骨折术后采用药物抵抗骨质疏松并预防再次骨折的重要性。方法：选取本院238例实施手术的髋部骨折患者采用随机数字表法分为对照组和观察组，每组119例。对照组患者术后常规给予钙片口服治疗，观察组患者术后在常规钙片基础上，给予阿仑膦酸钠维D3片联合自制中药方剂。对比两组患者治疗前后的骨密度、骨代谢指标、治疗过程中的不良反应发生率。结果：治疗6个月后，观察组股骨颈、腰椎L1～4、Wards三角以及大转子的骨密度值（733.84±55.42） mg/cm2、（998.41±51.86） mg/cm2、（617.37±31.26） mg/cm2、（662.78±24.97） mg/cm2均高于對照组（654.15±42.84） mg/cm2、（912.74±38.51） mg/cm2、（537.81±27.18） mg/cm2、（619.64±28.94） mg/cm2，比较差异有统计学意义（P<0.05）。观察组治疗后的Pyd/Cr比值（43.68±8.69）低于对照组（66.59±11.36），比较差异有统计学意义（P<0.05）。结论：髋骨骨折术后给予中药联合阿仑膦酸钠维D3片抗骨质疏松治疗的临床效果确切，能更好地增加骨密度、缓解疼痛，利于骨折愈合，安全可靠。

【关键词】 髋骨骨折； 阿仑膦酸钠； 脱氧吡啶酚

Treatment of Osteoporotic Fracture and Prevention of Refracture after Hip Fracture/ZHANG Yang，DENG Sen，ZHU Xue-jia.//Medical Innovation of China，2017，14（14）：115-118

【Abstract】 Objective：To analyze the importance of drug resistance and prevention of fracture after hip fracture surgery.Method： A total of 238 cases with hip fracture were divided into the control group and the observation group according to the random number table method，119 cases in each group.The patients in the control group were given conventional oral calcium treatment，while the patients in the observation group were given Alendronate Sodium and VD3 Tablets combined with Chinese Medicine prescription on the basis of conventional tablets.The bone mineral density，bone metabolism index and the incidence of adverse reactions were compared between two groups before and after treatment.Result：After 6 months of treatment，femoral neck， lumbar L1-4，wards and great trochanter bone mineral density of the observation group （733.84±55.42）mg/cm2，

（998.41±51.86）mg/cm2，（617.37±31.26） mg/cm2，（662.78±24.97）mg/cm2 were higher than those in the control group （654.15±42.84）mg/cm2，（912.74±38.51）mg/cm2，（537.81±27.18）mg/cm2，（619.64±28.94）mg/cm2，the difference was statistically significant（P<0.05）.After treatment，Pyd/Cr ratio of the observation group （43.68±8.69） was lower than that of the control group （66.59±8.69），the difference was statistically significant（P<0.05）.Conclusion：The clinical efficacy of Chinese Medicine combined with Alendronate Sodium and VD3 Tablet used in the treatment of hip fracture can increase the bone density and relieve the pain of patients，which is good for fracture healing，has definite therapeutic effect.

【Key words】 Hip fracture； Alendronate Sodium； Deoxy Pyridinoline

First-authors address：Gaozhou Municipal Hospital of Traditional Chinese Medicine，Gaozhou 525200，China