张榕华+黄朝发+黄小荣+郑桂英

[摘要]目的 研究疏血通注射液联合单硝酸异山梨酯治疗冠心病不稳定型心绞痛（UAP）的效果及安全性。方法 选择2014年8月～2016年8月在我院进行诊治的56例冠心病UAP患者，随机分为对照组和观察组，各28例。对照组采用疏血通注射液治疗，观察组采用疏血通注射液联合单硝酸异山梨醋注射液治疗。比较两组治疗前后的丙氨酸氨基转移酶（ALT）、纤维蛋白原（FIB）及血肌酐（SCr）水平以及临床效果。结果 观察组的治疗总有效率为92.86%，高于对照组的71.43%，差异有统计学意义（P<0.05）。观察组治疗后的FIB水平显著低于治疗前及对照组治疗后，差异有统计学意义（P<0.05）。观察组治疗后的ALT及SCr水平与对照组比较，差异无统计学意义（P>0.05）。结论 疏血通注射液联合单硝酸异山梨醋治疗冠心病UAP效果显著，适合推广。

[关键词]疏血通注射液；单硝酸异山梨醋注射液；不稳定性心绞痛

[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-4721（2017）04（a）-0045-03

Efficacy and safety of Shuxuetong Injection combined with Isosorbide Mononitrate in the treatment of unstable angina pectoris

ZHANG Rong-hua HUANG Chao-fa HUANG Xiao-rong ZHENG Gui-ying

Department of Internal Medicine-Cardiovascular，People′s Hospital of Shangrao County in Jiangxi Province，Shangrao 334100，China

[Abstract]Objective To study the efficacy and safety of Shuxuetong Injection combined with Isosorbide Mononitrate in the treatment of unstable angina pectoris （UAP） of coronary heart disease （CHD）.Methods 56 patients with UAP of CHD who were treated in our hospital from August 2014 to August 2016 were selected and randomly divided into the control group and the observation group，28 cases in each group.The control group was treated with Shuxuetong Injection ，the observation group was treated with Shuxuetong Injection combined with Isosorbide Mononitrate Injection.The levels of Alanine aminotransferase （ALT），fibrinogen （FIB） and serum creatinine （SCr） and clinical efficacy were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 92.86%，which was higher than that of the control group （71.43%），with significant difference （P<0.05）.The level of FIB after treatment in the observation group was lower than that before treatment and in the control group，with significant difference （P<0.05）.There was no significant difference in the level of ALT and SCr after treatment between the observation group and the control group （P>0.05）.Conclusion The effect of Shuxuetong Injection and Isosorbide Mononitrate Injection in the treatment of UAP of CHD is significant，which is worthy of promotion.

[Key words]Shuxuetong Injection；Isosorbide Mononitrate Injection；Unstable angina pectoris

冠心病是一種临床上发病率较高的心脏疾病，该病的发病机制为冠状动脉发生狭窄和缺血，造成心肌功能出现障碍[1-4]。不稳定型心绞痛（unstable angina pectoris，UAP）是较为常见的一种冠心病，其发病机制为不稳定的粥样硬化斑块破裂引起血小板聚集堵塞，使心肌暂时出现急剧缺血缺氧，引起患者出现胸痛和胸部不适[5-6]。近年来，随着UAP发生率和死亡人数的不断增加，UAP的防治愈发受到人们的重视[7]。本研究选取我院诊治的冠心病UAP患者作为研究对象，探讨疏血通和单硝酸异山梨酯的治疗效果，现报道如下。

1资料与方法

1.1一般资料

选择2014年8月～2016年8月在我院进行诊治的56例冠心病UAP患者，随机分为对照组和观察组，各28例。观察组中，男15例，女13例；年龄46～75岁，平均（63.4±6.7）岁；……