曹文慧　张忠民　栗昭生　曲娜

[摘要] 目的 讨论阿加曲班对急性脑梗死的临床效果。 方法 选取我院2015年2月～2016年7月收治的54例急性脑梗死患者进行观察，分为观察组和对照组，对照组患者实施常规的阿司匹林治疗，观察组实施阿加曲班治疗。观察两组患者治疗后的治疗效果以及两组患者CSS、BI评分情况。 结果 观察组患者的有效率为96.30%，明显高于对照组的81.48%；治疗后两组的神经功能以及日常生活功能均有不同程度改善，观察组CSS、BI评分好于对照组，差异有统计学意义（P<0.05）；两组患者在不良反应方面无差异。 结论 阿加曲班治疗可以有效地提高急性脑梗死患者的治疗效果，提升患者的生活质量，保障患者的生命安全，具有非常重要的意义。

[关键词] 阿加曲班；急性脑梗死；心血管疾病

[中图分类号] R743.33 [文献标识码] B [文章编号] 1673-9701（2017）06-0103-03

[Abstract] Objective To investigate the clinical effect of Argatroban on acute cerebral infarction. Methods 54 patients with acute cerebral infarction in our hospital from February 2015 to July 2016 were enrolled in this study. The patients were divided into two groups including observation group and control group. The control group was treated with conventional aspirin. The observation group was given argatroban treatment. the therapeutic effect of the two groups after treatment and the CSS and BI scores of the two groups were compared. Results The effective rate was 96.30% in the observation group， higher than 81.48% in the control group. The neurological function and the daily life function of the two groups were improved to varying degrees after treatment. The scores of CSS and BI in the observation group were better than those in the control group， there were significant differences in the scores between the two groups（P<0.05）. There were no difference in the adverse reactions between the two groups of patients. Conclusion The treatment of argatroban， which improves the quality of life of patients and ensures the safety of patients， can effectively improve the therapeutic effect of patients with acute cerebral infarction and has a very important significance.

[Key words] Argatroban； Acute cerebral infarction； Cardiovascular disease

脑梗死又称脑梗塞，是指腦部出现缺血性卒中的情况，是脑部血液供应出现障碍导致的。该疾病的病因以心源性和非心源性为主。临床症状主要为面瘫、上肢偏瘫、失语、抽搐等，严重的会出现眩晕、复视等情况，还会引发心律失常等，危及患者的生命安全。该病无特定的发病人群，任何年龄段均能发生，该病在发病时无任何前兆，患者有时仅在几分钟就能达到病情的高峰期。所以有效的治疗方式是保障急性脑梗死患者生命的关键[1]，因此，为了研究阿加曲班对急性脑梗死的效果，我院特选取2015年2月～2016年7月收治的54例急性脑梗死患者进行观察，现报道如下。

1 资料与方法

1.1 一般资料

选取我院2015年2月～2016年7月收治的54例急性脑梗死患者进行观察，根据治疗方式随机分为两组，观察组和对照组，其中观察组27例，男14例，女13例，年龄35～70岁，平均（66.21±1.32）岁；……