喻晖　梅益斌　张伟

[摘要] 目的 探讨临床使用维拉帕米片发生药物不良反应的影响因素。 方法 收集本院124例维拉帕米片不良反应患者资料，对患者使用维拉帕米的临床特点和影响因素进行统计分析。 结果 不良反应发生率男性高于女性；发生不良反应的患者中累及的系统和器官以心血管不良反应的比例最高（38.71%），其次是神经系统不良反应（31.45%）。维拉帕米片不良反应的可疑因素主要为患者的性别、年龄、用药频率、服药剂量、疗程、合并用药和既往过敏史。 结论 应用盐酸维拉帕米治疗心绞痛，需要对患者的年龄，既往过敏史和病史进行详细的了解，才能保障用药安全。

[关键词] 维拉帕米片；不良反应；影响因素；Logistic回归分析

[中图分类号] R972 [文献标识码] B [文章编号] 1673-9701（2017）06-0106-03

[Abstract] Objective To explore the suspected influencing factors of adverse drug reactions of the clinical application of verapamil tablets. Methods Data of 124 patients with adverse reactions due to the administration of verapamil tablets were collected in our hospital. The clinical characteristics and influencing factors of verapamil were analyzed statistically. Results The incidence of adverse reactions was higher in males than in females； the proportion of cardiovascular adverse reactions was the highest among the affected systems and organs in the patients with adverse reactions （38.71%）， followed by the nervous system adverse reactions（31.45%）. The suspected factors of the adverse effects of verapamil tablets were mainly gender， age， frequency of administration， dose， course of treatment， drug combination and past history of allergies. Conclusion The application of verapamil hydrochloride in the treatment of angina pectoris needs to have a detailed understanding of the age， past history of allergies and disease history of the patients， in order to ensure the safety of medication.

[Key words] Verapamil tablets；Adverse reactions；Influencing factors；Logistic regression analysis

維拉帕米是一种罂粟碱的衍生物，常作为钙离子内流的抑制剂。在心脏当中，窦房结和房室结的自律性会因钙离子内流的一致而降低，进而也会使窦房结的发放冲动减慢，也可减慢传导，从而可消除房室结折返，缓解心绞痛[1-3]。本文收集本医院124例维拉帕米片不良反应患者，统计患者的相关资料，然后使用Logistic回归分析对维拉帕米片不良反应的相关因素进行分析。现报道如下。

1 资料与方法

1.1一般资料

在2014年8月～2016年8月，随机选择124例具有完整病理资料的患者进行统计分析。纳入标准：（1）住院期间发生维拉帕米片不良反应；（2）患者的基本信息完整；（3）患者发生不良反应的类型、整个治疗过程中给药情况都有详细记录。……