喻慧 徐斌权 宋卫国 贺支支

【摘要】目的：觀察益肾化瘀利水汤联合热敏灸治疗原发性肾病综合征的临床疗效。方法：将60例原发性肾病综合征患者随机均分为两组，两组均接受一般治疗。对照组30例加用百令胶囊治疗，治疗组30例加用益肾化瘀利水汤联合热敏灸治疗。治疗12周后观察两组24h尿蛋白、血浆白蛋白、总胆固醇、甘油三酯、血肌酐等数值变化情况及副反应发生率。结果：治疗组总有效率高于对照组（P<005）；两组治疗后24h尿蛋白定量、血浆白蛋白、总胆固醇、甘油三酯均下降，但治疗组明显低于对照组（P<005）；治疗组不良反应发生率低于对照组，两组不良反应发生率差异具有统计学意义（P<005）。结论：益肾化瘀利水汤联合热敏灸治疗原发性肾病综合征，临床疗效较好，且不良反应较少，值得临床推广。

【关键词】益肾化瘀利水汤；热敏灸；原发性肾病综合征

【中图分类号】R692【文献标志码】 A【文章编号】1007-8517（2017）07-0135-04

Therapeutic Effect of Tonifying Kidney and Removing Blood Stasis and Alleviating Water Retention Decoction Combined Moxibustion at Heat -sensitive Points for Primary Nephrotic Syndrome：30 Cases

YU Hui1XU Binquan2SONG Weiguo3*HE Zhizhi3

1Jiangxi University of Traditional Chinese Medicine Graduate School，Nanchang 330000，China；2Shenzhen Baoan District Hospital of TCM，Shenzhen 518100，China；3Jiangxi University of Traditional Chinese Medicine Hospital，Nanchang 330000，China

Abstract：Objective To observe the clinical effect of tonifying kidney and removing blood stasis and alleviating water retention decoction combined moxibustion at heat-sensitive points in primary nephrotic syndrome.Methods Methods 60 patients with primary nephrotic syndrome were randomly divided into the treatment group and the control group. The patients in the two groups received general treatment.The control group of 30 cases with Bailing Capsule treatment， 30 cases in the treatment group added the tonifying kidney and removing blood stasis and alleviating water retention decoction combined moxibustion at heat- sensitive points therapy.After 12 weeks of treatment， the changes of 24h urinary protein， plasma albumin， total cholesterol， triglyceride， serum creatinine and the incidence of side effects were observed in the two groups. Results The total effective rate of treatment group was higher than that of control group （P<005）； the two group after treatment， 24h urinary protein， serum albumin， total cholesterol and triglyceride were decreased， but the treatment group was significantly lower than the control group （P<005）； and the incidence of adverse reaction in treatment group than in the control group， adverse reaction rate between the two groups with statistical significance （P<005）. Conclusion The tonifying kidney and removing blood stasis and alleviating water retention decoction combined moxibustion at heat- sensitive points in the treatment of primary nephrotic syndrome， clinical curative effect is better， and less adverse reactions， worthy of clinical promotion.

Keywords：Tonifying Kidney and Removing Blood Stasis and Alleviating Water Retention Decoction；Moxibustion on Temperature-sensitive Points；Primary Nephrotic Syndrome

肾病综合征（Nephrotic Syndrome， NS） 是一组特点为大量蛋白尿、低蛋白血症、高脂血症和水肿的临床综合征，其最基本的特征是大量蛋白尿（≥35g/d）伴低白蛋白血症（≤30g/L）。本病发病迅速且极易复发，会出现感染、血栓、栓塞、急性肾功能损伤、蛋白质营养不良等严重并发症[1]。目前，西医治疗首选糖皮质激素，疗效不佳时常联合细胞毒性药物，虽然可取得一定疗效， 但存在不良反应大、易复发、易产生激素依赖等问题[2]。而采用中药内服配合中医特色外治法可以提高疗效，减轻不良反应。本研究在常规内科治疗的基础上予益肾化瘀利水汤联合热敏灸治疗原发性肾病综合征30例，疗效较好，现报道如下。

1资料与方法

11一般资料观察病例均为2015年10月至2016年10月在江西中医药大学附属医院肾内科门诊及住院部就诊的患者，共60例，随机分为两组。对照组30例，其中男17例，女13例，年龄23～67岁，平均年龄（4471±1684）岁；病程为6个月至2年半，平均病程（152±036）年。……