朱碧华

【摘要】 目的：观察慢性丙型肝炎药物治疗不良反应情况及中医护理效果。方法：选取2015年

5月-2016年8月医院收治慢性丙型肝炎患者90例，入院患者均采用干扰素联合利巴韦林治疗，观察患者治疗过程中不良反应情况。根据护理方案不同分为对照组和观察组，每组各45例，对照组采用常规方法护理，观察组采用中医护理，比较两组护理效果及治疗依从性情况。结果：90例患者治疗过程中20例发生不良反应，发生率为22.22%，排在前两位的为体重下降及脱发，分别占25.00%、20.00%；观察组护理后SDS及SAS量表评分低于对照组（P<0.05）。结论：慢性丙型肝炎患者采用干扰素联合利巴韦林治疗药物不良反应发生率较高，加强患者中医护理能提高患者治疗依从性，降低心理波动，值得推广应用。

【关键词】 慢性丙型肝炎； 药物治疗； 不良反应； 中医护理； 心理波动

【Abstract】 Objective：To observe the adverse drug reaction of chronic hepatitis C and the nursing effect of traditional Chinese medicine.Method：90 cases with chronic hepatitis C in our hospital were selected from May 2015 to August 2016，the patients were treated of Interferon combined with Ribavirin，the adverse reactions of patients were observed.They were divided into control group and observation group according to the different nursing methods，45 cases in each group.The control group received conventional nursing，the observation group was given the traditional Chinese medicine nursing，the nursing effects and treatment compliance of two groups were compared.Result：20 cases of adverse reactions occurred in 90 patients，the incidence rate of 22.22%， ranked in the top two were weight loss and hair loss， which accounted for 25.00% and 20.00%.After nursing， the SDS and SAS scores in observation group were lower than the control group（P<0.05）.Conclusion：Patients with chronic hepatitis C treated with Interferon combined with Ribavirin in the treatment of adverse drug reaction occurred at a higher rate， strengthen the nursing care of patients with traditional Chinese medicine can improve the treatment compliance of patients，reduce the psychological fluctuations，it is worthy of popularization and application.

【Key words】 Chronic hepatitis C； Drug therapy； Adverse reaction； Traditional Chinese medicine nursing； Psychological fluctuation

First-authors address：Zengcheng District Hospital of Traditional Chinese Medicine，Guangzhou 511300，China

doi：10.3969/j.issn.1674-4985.2017.07.039

慢性丙型肝炎是由于丙型肝炎病毒（HCV）感染所致，从而引起肝脏慢性炎症，发病后如果得不到及时有效的治疗，将会引起肝脏坏死、纤维化，严重者将会演变为肝硬化、肝癌，威胁患者生命[1]。常规方法以干扰素联合利巴韦林治疗为主，是临床治疗慢性丙型肝炎的标准治疗方案，能有效地降低病毒载量，降低复发率，但是该治疗方案病程相对较长，治疗费用较高，患者治疗过程中药物不良反应发生率较高，导致患者治疗依从性较差[2-3]。因此，慢性丙型肝炎患者治疗过程中加强患者护理对提高治疗依从性，降低心理波动具有重要的意义。……