邱嘉华+陈丽+谢小月

【摘要】 目的 研究中藥辅助治疗急性胰腺炎的临床疗效。方法 64例急性胰腺炎患者， 随机分成对照组和治疗组， 各32例。对照组给予禁食、持续肠胃减压、抑酸、抑制胰腺分泌、防治水电解质紊乱等内科综合治疗；治疗组在对照组内科综合治疗的基础上给予中药胃管内注入或口服。观察两组患者的临床治疗效果， 并于治疗前后比较两组血清C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）等水平。结果 治疗组治疗总有效率为90.63%， 高于对照组的68.75%， 差异具有统计学意义（P<0.05）。治疗前， 两组患者血清 CRP、 IL-6、IL-10水平比较差异均无统计学意义（ P>0.05）。治疗后， 两组胰腺炎患者血清CRP、IL-6、IL-10均较治疗前显著下降， 且治疗组下降更明显， 差异有统计学意义（P<0.05）。结论 中药辅助常规内科综合治疗急性胰腺炎能快速清除炎症因子， 起到多靶点干预治疗的作用， 提高了临床疗效， 值得临床推广。

【关键词】 急性胰腺炎；白细胞介素-6；白细胞介素-10；中药；内科综合治疗

DOI：10.14163/j.cnki.11-5547/r.2017.01.015

Observation of clinical effect by traditional Chinese medicine in adjuvant therapy for acute pancreatitis QIU Jia-hua， CHEN Li， XIE Xiao-yue. Department of Gastroenterology， Shenzhen City Longhua New District Peoples Hospital/Affiliated Hospital of Southern Medical University， Shenzhen 518000， China

【Abstract】 Objective To research clinical effect by traditional Chinese medicine in adjuvant therapy for acute pancreatitis. Methods A total of 64 patients with acute pancreatitis were randomly divided into control group and treatment group， with 32 cases in each group. The control group received internal medical comprehensive treatment by abrosia， continuous gastrointestinal decompression， acid inhibition， pancreatic secretion inhibition， and water and electrolyte disturbance prevention. The treatment group received additional traditional Chinese medicine by stomach tube injection or oral administration to internal medical comprehensive treatment in the control group. Observation was made on clinical effects in the two groups. Serum C-reactive protein （CRP）， interleukin-6 （IL-6） and interleukin-10 （IL-10） levels before and after treatment were compared between the two groups. Results The treatment group had higher total effective rate as 90.63% than 68.75% in the control group， and their difference had statistical significance （P<0.05）. Before treatment， there was no statistically significant difference of serum CRP， IL-6 and IL-10 levels between the two groups （P>0.05）. After treatment， both groups had obviously lower serum CRP， IL-6 and IL-10 levels than those before treatment， and the treatment group had much more obvious decreasing levels. Their difference had statistical significance （P<0.05）. Conclusion Traditional Chinese medicine in adjuvant therapy for acute pancreatitis can rapidly eliminate inflammatory factor and provide multiple targeted prevention and treatment effect， along with improved clinical effect. This method is worth clinical promotion.

【Key words】 Acute pancreatitis； Interleukin-6； Interleukin-10； Traditional Chinese medicine； Internal medical comprehensive treatment

急性胰腺炎是消化系统的急危重症， 具有较高的发病率， 且并发症多[1]。临床表现为腹痛、腹胀、恶心、呕吐、发热等一系列症状， 伴有胰腺的水肿、充血， 或出血、坏死。常规内科综合治疗为禁食、持续胃肠减压、抑制胃酸和胰液分泌、防治水电解质紊乱以及必要时镇痛等对症支持治疗[2-4]。近几年来， 治疗急性胰腺炎的疗效有了很大的提高， 中药辅助治疗急性胰腺炎逐渐被采用， 使急性胰腺炎的预后大为改善[5]。2013年8月～2015年7月本院收治了64例急性胰腺炎患者， 采用中药胃管内注入或口服治疗32例， 效果显著， 现报告如下。

1 资料与方法

1. 1 一般资料 选择2013年8月～2015年7月本院收治的64例急性胰腺炎患者为研究对象， 主要症状：腹痛腹胀、恶心呕吐、发热；……