朱坎贤+李平+方圆

【摘要】 目的：探討葡萄糖酸锌在改善腹泻患儿炎症状态及近期疗效中的应用。方法：选取2013年1月-2015年10月本院确诊治疗的腹泻患儿40例，依据随机分配原则分为对照组和观察组，每组20例，对照组患儿给予临床常规治疗，观察组患儿在此基础上给予口服葡萄糖酸锌片治疗（10 mg/kg，2次/d，持续1个月），统计分析两组患儿临床症状（腹泻、呕吐、发热）消退时间和治疗效果，以及采用酶联免疫吸附法检测治疗前后患儿血清中白细胞介素-1（IL-1）、白细胞介素-12（IL-12）水平及不良反应发生情况。结果：观察组患儿止泻、止吐、退热时间均明显短于对照组，差异均有统计学意义（P<0.05）；观察组患儿治疗总有效率明显高于对照组，差异有统计学意义（P<0.05）；观察组患儿治疗后血清中IL-1表达水平明显高于对照组，血清中IL-12表达水平明显低于对照组，差异均有统计学意义（P<0.05）；对照组和观察组不良反应发生率基本相同，差异无统计学意义（P>0.05）。结论：葡萄糖酸锌治疗可有效缓解腹泻患儿的临床症状，提高近期疗效，改善机体炎症状态，且具有良好的安全性，值得临床作进一步推广。

【关键词】 葡萄糖酸锌； 小儿腹泻； 疗效； 炎症状态

【Abstract】 Objective：To discuss the application of Zinc Gluconate in improving the inflammation state and the recent curative effect of infantile diarrhea.Method：A total of 40 children with infantile diarrhea were selected from January 2013 to October 2015 in our hospital.According to the random distribution，all children were divided into the observation group and the control group，20 cases in each group，the control group received conventional treatment，on the basis of the control group the observation group received oral Zinc Gluconate （10 mg/kg，2 times/d，for 1 months），children with clinical symptoms，diarrhea，vomiting，fever subsided time and treatment effect，and before and after treatment were detected by enzyme-linked immunosorbent method with serum interleukin 1（IL-1），interleukin 12（IL-12） level and adverse reactions of two groups were analyzed.Result：The antidiarrheal， anti-nausea，antifebrile time of the observation group were significantly shorter than those of the control group，the differences were statistically significant（P<0.05）.The total effective rate of the observation group was obviously higher than that of the control group（P<0.05）.After treatment serum IL-1 expression levels of the observation groupwas significantly higher than that of the control group，serum IL-12 expression level was significantly lower than that of the control group（P<0.05）.The incidence of adverse reactions of two groups were basically the same，there was no significant difference（P>0.05）.Conclusion：Zinc Gluconate can effectively alleviate the clinical symptoms of infantile diarrhea，improve the recent curative effect of infantile diarrhea and body's inflammatory state，and has good security，its worth of further clinical promotion.

【Key words】 Zinc Gluconate； Infantile diarrhea； Curative effect； Inflammatory state

First-authors address：The Second Hospital of Zhanjiang Nongken Guangdong Province，Zhanjiang 524272，China

doi：10.3969/j.issn.1674-4985.2016.34.017

小儿腹泻是由多病原、多因素引起的以腹泻为主的一组疾病，其主要临床表现有大便次数增多和性状改变，可伴有发热、呕吐、腹痛等症状，可引起机体内水、电解质失衡，而高热可使小儿大脑皮质过度兴奋，容易发生高热惊厥，有时还可以使感染和创伤所致的炎症反应加重，危害患儿的身体健康[1-2]。目前，小儿腹泻多采用临床对症支持治疗，如抗感染、消炎、止泻、补液等治疗，可有效缓解患儿临床症状，但在停止治疗后，仍有一部分患儿会出现呕吐、发热等症状，在一定程度上降低治疗效果[3-4]。因此，如何彻底有效缓解患儿腹泻症状，改善机体内水、电解质失衡以提高临床疗效和预后水平是儿科医师重点关注的问题。……